Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies.
Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies.
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发表时间：
2003
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通讯作者：
Paul A. Cannistraro;S. Rauch
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作者：
Paul A. Cannistraro;S. Rauch
目前对焦虑神经回路的理解来自多种来源，包括动物、临床和最近的神经影像学研究。来自这些来源的证据已经汇聚在一起，形成了从动物模型到人类病理生理学的转化桥梁。特别是，经典的恐惧调节范式已成为这座桥梁的基础。讨论了正常焦虑和焦虑症的神经回路的拟议模型。还简要回顾了创伤后应激障碍、特定恐惧症、社交恐惧症、强迫症和广泛性焦虑症的神经影像学研究的具体结果。
Present understanding of the neural circuitry of anxiety has come from a variety of sources, including animal, clinical, and most recently, neuroimaging studies. Evidence from these sources has converged to form a translational bridge from animal models to human pathophysiology. In particular, the classical fear conditioning paradigm has served as a foundation for this bridge. Proposed models for the neural circuitry of normal anxiety as well as the anxiety disorders are discussed. A brief review of specific findings from neuroimaging studies of posttraumatic stress disorder, specific phobia, social phobia, obsessive-compulsive disorder, and generalized anxiety disorder is also provided.