Screening of TNF- gene polymorphisms in patients with extremity chronic osteomyelitis in China
Screening of TNF- gene polymorphisms in patients with extremity chronic osteomyelitis in China
复制标题
我国四肢慢性骨髓炎患者TNF-α基因多态性筛查
DOI：
10.2217/pme-2018-0017
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发表时间：
2018-09-01
影响因子：
2.3
通讯作者：
Yu, Bin
中科院分区：
文献类型：
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作者：
Hou, Yilong;Bai, Lang;Yu, Bin
目的：探讨肿瘤坏死因子基因单核苷酸多态性与中国人肢体慢性骨髓炎的关系。方法：我们的研究包括433名受试者，包括233名四肢慢性骨髓炎患者和200名对照。采用SNaPshot基因分型方法检测TNF-α基因rs 1799964、rs 1800630、rs 1799724、rs 1800750、rs 1800629和rs361525 6个单核苷酸多态性位点。结果：rs 1799964的基因型分布在患者和健康对照组之间具有显著性差异（p=0.045）。此外，rs 1799964 SNP与肢体慢性骨髓炎易感性之间存在统计学差异（p=0.044）。结论：本文首次报道了TNF-α基因rs 1799964单核苷酸多态性与我国肢体慢性骨髓炎发病风险的关系。
Aim: This study aims to investigate the link between TNF- gene SNPs and patients with extremity chronic osteomyelitis in China. Methodology: Our study included 433 subjects, composed of 233 extremity chronic osteomyelitis patients and 200 controls. Six single-nucleotide polymorphisms (rs1799964, rs1800630, rs1799724, rs1800750, rs1800629 and rs361525) in TNF- gene were detected by the SNaPshot genotyping method. Results: Significant genotype distribution of rs1799964 was identified between patients and healthy controls (p=0.045). In addition, statistical difference was found between rs1799964 SNP and the susceptibility to extremity chronic osteomyelitis (p=0.044). Conclusion: We reported for the first time that TNF- gene SNP rs1799964 contributes to the elevated venture of extremity chronic osteomyelitis in China.