Cell-cycle-based strategies to drive myocardial repair.
Cell-cycle-based strategies to drive myocardial repair.
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基于细胞周期的策略来驱动心肌修复。
DOI：
10.1007/s00246-009-9408-3
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发表时间：
2009
影响因子：
1.6
通讯作者：
Field,LorenJ
中科院分区：
文献类型：
--
作者：
Zhu,Wuqiang;Hassink,RutgerJ;Rubart,Michael;Field,LorenJ
心肌细胞在发育过程中表现出强烈的增殖活性。出生后，心肌细胞增殖明显减少。因此，出生后心脏通过心肌细胞增殖（以及干细胞衍生的心肌细胞的增殖）的再生生长是有限的，并且通常不足以影响损伤后的修复。在这里，我们回顾研究，其中心肌细胞周期增殖诱导通过有针对性地表达细胞周期蛋白D2在出生后的心脏。细胞周期蛋白D2的表达导致转基因小鼠的细胞周期活性比非转基因小鼠增加500倍以上。诱导的细胞周期活性导致梗死消退和伴随的冠状动脉闭塞后心脏血流动力学的改善。这些研究支持了这样的观点，即可以利用基于细胞周期的策略来驱动损伤后的心肌修复。
Cardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte proliferation is markedly reduced. Consequently, regenerative growth in the postnatal heart via cardiomyocyte proliferation (and, by inference, proliferation of stem-cell-derived cardiomyocytes) is limited and often insufficient to affect repair following injury. Here, we review studies wherein cardiomyocyte cell cycle proliferation was induced via targeted expression of cyclin D2 in postnatal hearts. Cyclin D2 expression resulted in a greater than 500-fold increase in cell cycle activity in transgenic mice as compared to their nontransgenic siblings. Induced cell cycle activity resulted in infarct regression and concomitant improvement in cardiac hemodynamics following coronary artery occlusion. These studies support the notion that cell-cycle-based strategies can be exploited to drive myocardial repair following injury.