Association of specific subtypes of Borrelia burgdorferi with hematogenous dissemination in early Lyme disease
Association of specific subtypes of Borrelia burgdorferi with hematogenous dissemination in early Lyme disease
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DOI：
10.1086/314922
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发表时间：
1999-09-01
影响因子：
6.4
通讯作者：
Schwartz, I
中科院分区：
文献类型：
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作者：
Wormser, GP;Liveris, D;Schwartz, I
为了研究狭义伯氏疏螺旋体的遗传多样性是否可能影响血行播散的发生，对来自纽约韦斯特切斯特县莱姆病诊断中心的104例未经治疗的游走性红斑成人进行了研究。用聚合酶链反应扩增和限制性片段长度多态性（RFLP）方法将培养的皮肤分离株分为3组。发现皮肤感染RFLP类型与螺旋体血症的存在高度显著相关（P
To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classified into 3 groups by a polymerase chain reaction amplification and restriction fragment length polymorphism (RFLP) method. A highly significant association between infecting RFLP type in skin and the presence of spirochetemia was found (P