Interactions between thalamic and cortical rhythms during semantic memory recall in human.
Interactions between thalamic and cortical rhythms during semantic memory recall in human.
复制标题
人类语义记忆回忆过程中丘脑和皮质节律之间的相互作用。
DOI：
10.1073/pnas.092514899
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
HartJr,John
中科院分区：
文献类型：
--
作者：
Slotnick,ScottD;Moo,LaurenR;Kraut,MichaelA;Lesser,RonaldP;HartJr,John
人类头皮脑电图的节律，表明皮质人口的同步性，长期以来一直被认为是反映认知过程。虽然大量的研究采用丘脑和皮层电极同时记录在非人类动物中探索了丘脑在皮层节律调制中的作用，但据我们所知，还没有获得人类丘脑皮层调制的直接证据。我们同时记录从丘脑和头皮电极在一个人在执行认知任务，并发现了一个空间广泛的，锁相，低频节奏（7-8 Hz）的功率下降在丘脑和头皮语义记忆回忆。这种低频节律功率降低之后，丘脑和枕部头皮出现空间特异性、锁相、快节律（21-34 Hz）功率增加。这种丘脑皮层活动模式反映了语义记忆回忆背后的一种合理的神经机制，这种机制也可能是其他认知过程的基础。
Human scalp electroencephalographic rhythms, indicative of cortical population synchrony, have long been posited to reflect cognitive processing. Although numerous studies employing simultaneous thalamic and cortical electrode recording in nonhuman animals have explored the role of the thalamus in the modulation of cortical rhythms, direct evidence for thalamocortical modulation in human has not, to our knowledge, been obtained. We simultaneously recorded from thalamic and scalp electrodes in one human during performance of a cognitive task and found a spatially widespread, phase-locked, low-frequency rhythm (7–8 Hz) power decrease at thalamus and scalp during semantic memory recall. This low-frequency rhythm power decrease was followed by a spatially specific, phase-locked, fast-rhythm (21–34 Hz) power increase at thalamus and occipital scalp. Such a pattern of thalamocortical activity reflects a plausible neural mechanism underlying semantic memory recall that may underlie other cognitive processes as well.