Phaeohyphomycosis Caused by a Novel Species, Pseudochaetosphaeronema martinelli
Phaeohyphomycosis Caused by a Novel Species, Pseudochaetosphaeronema martinelli
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DOI：
10.1128/jcm.01456-15
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发表时间：
2015-09-01
影响因子：
9.4
通讯作者：
de Hoog, G. Sybren
中科院分区：
文献类型：
--
作者：
Ahmed, Sarah A.;Desbois, Nicole;de Hoog, G. Sybren
在免疫抑制或严重基础疾病患者中出现的机会性真菌病中，许多分离株缺乏特征性孢子形成，直到最近才得以鉴定。临床症状大多是非特异性的，因此这种感染往往被忽视。在本文中，我们描述了一种新的，非孢子化真菌物种引起皮下暗色丝孢霉病在两个不同来源的患者。其中一例是来自马提尼克岛的73岁女性，患有类风湿性关节炎，另一例是来自墨西哥的72岁男性，有2型糖尿病史。部分核糖体操纵子的测序显示，在这两种情况下，一个成员的目的Pleosporales的关注，不能隶属于任何家庭在这个命令。多位点分析显示，该真菌与人类足菌肿的另一种独立因子Pseudochaetosphaeronema larense有关，因此引入了Pseudochaetosphaeronema martinelli的名称。
Among the opportunistic mycoses that are emerging in patients with immunosuppression or severe underlying illness, many isolates lack of characteristic sporulation and until recently could not be identified. Clinical signs are mostly nonspecific and therefore such infections have often been disregarded. In the present paper we describe a novel, nonsporulating fungal species causing subcutaneous phaeohyphomycosis in two patients of different origin. One is a 73-year-old female from Martinique who suffered from rheumatoid arthritis, while the other case concerns a 72-year-old male from Mexico who had a history of type 2 diabetes mellitus. Sequencing of the partial ribosomal operon revealed that in both cases a member of the order Pleosporales was concerned which could not be affiliated to any family within this order. Multilocus analysis revealed that the fungus was related to another, unaffiliated agent of human mycetoma, Pseudochaetosphaeronema larense, and therefore the name Pseudochaetosphaeronema martinelli was introduced.