Simulation of vessel morphogenesis using cellular automata
Simulation of vessel morphogenesis using cellular automata
复制标题
DOI：
10.1016/s0025-5564(98)10066-4
复制
发表时间：
1999-03-01
影响因子：
4.3
通讯作者：
Schmick, M
中科院分区：
文献类型：
--
作者：
Markus, M;Böhm, D;Schmick, M
我们提出了一个细胞自动机模型，包括横向抑制的自催化形态，以及一个遗传开关，分化成基板耗尽血管组织。该模型产生各向同性的形态发生，包括：二叉和横向分支，盲血管末端，以及由于吻合而形成的闭合环。该算法由一系列简单的规则组成，描述了基本的生物物理特征，允许舒适的编程和快速计算。根据底物s的选择，该模型适用于叶脉（s是生长素）、昆虫气管（s是CO2）或新血管形成（s是血管生成因子）。规则的顺序添加可以与叶形态发生中的进化步骤相关。(C)1999 Elsevier Science Inc. All rights reserved.
We present a cellular automaton model, including lateral inhibition of an autocatalytic morphogen, as well as a genetic switch that differentiates tissue into substrate-depleting vessels. This model yields isotropic morphogenesis, including: dichotomous and lateral branching, blind vessel ends, and closed loops due to anastosmosis. The algorithm consists of a list of simple rules describing the essential biophysical features, permitting comfortable programming and fast computations. Depending on the choice of the substrate s, the model is applicable to leaf veins (s is auxin), insect trachea (s is CO2) or neovascularization (s is an angiogenesis factor). Sequential addition of rules can be correlated to evolutionary steps in leaf morphogenesis. (C) 1999 Elsevier Science Inc. All rights reserved.