Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation
Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation
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DOI：
10.1006/cyto.1996.0114
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发表时间：
1996-11-01
期刊：
影响因子：
3.8
通讯作者：
Chaudry, IH
中科院分区：
文献类型：
--
作者：
Wichmann, MW;Zellweger, R;Chaudry, IH
虽然失血性休克在人类和实验动物中都会产生免疫抑制，但目前还没有关于休克免疫和内分泌反应的性别差异的信息。为了研究这一点，雄性和雌性(动情前期和动情间期)C3H/HEN小鼠(体重25g)失血并维持平均动脉压35+/-5毫米汞柱1h，然后充分复苏。复苏后2小时处死动物，取脾细胞、巨噬细胞(M phi、腹膜和脾)及全血。能显著提高雌性小鼠脾细胞增殖能力和IL-3的释放。然而，雄性小鼠在休克后表现出所有白介素1、2、3、6的释放减少以及脾细胞的增殖能力。发情前期雌性小鼠血浆皮质酮水平降低，而雄性小鼠休克后血浆皮质酮水平升高。因此，皮质酮是造成观察到的性别差异的部分原因。据作者所知，这是第一项表明失血性休克后雌性小鼠的免疫反应性增强的研究，而不是雄性小鼠的免疫反应性降低。因此，与表现出对败血症/感染易感性增加的男性不同，女性应该能够更好地耐受休克的有害影响。(C)1996学术出版社有限公司。
Although haemorrhagic shock produces immunodepression in both humans and experimental animals, no information is available concerning gender differences in the immune and endocrine response to shock. To study this, male and female (proestrus and diestrus) C3H/HeN mice (25 g body weight) were bled and maintained at a mean arterial blood pressure of 35 +/- 5 mmHg for 1 h and then adequately resuscitated. The animals were killed at 2 h after resuscitation to obtain splenocytes, macrophages (M phi, peritoneal and splenic), as well as whole blood. IL-l release by M phi, splenocyte proliferative capacity and splenocyte IL-3 release in female mice was significantly increased. Male mice, however, showed decreased release of all interleukins (IL-1, 2, 3, 6) as well as splenocyte proliferative capacity after shock. Plasma corticosterone levels decreased in proestrus female mice, as opposed to increased levels in males following shock. Corticosterone mag therefore, be in part responsible for the observed gender differences. To the authors' knowledge, this is the first study which shows that immune responsiveness in female mice is enhanced after haemorrhagic shock, as opposed to decreased responsiveness in males. Thus, unlike males which exhibit increased susceptibility to sepsis/infections, females should be able to better tolerate the deleterious effects of shock. (C) 1996 Academic Press Limited.