Induction of regulatory properties in dendritic cells by Vα14 NKT cells
Induction of regulatory properties in dendritic cells by Vα14 NKT cells
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DOI：
10.4049/jimmunol.175.6.3648
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发表时间：
2005-09-15
影响因子：
4.4
通讯作者：
Taniguchi, M
中科院分区：
文献类型：
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作者：
Kojo, S;Seino, K;Taniguchi, M
V α 14 NKT细胞在体内表现出多种免疫调节特性，但其确切机制仍有待解决。在这项研究中，我们证明了调节性树突状细胞（DC）的产生机制，通过刺激V α 14 NKT细胞在体内。在向小鼠重复注射α-半乳糖神经酰胺（α-GalCer）后，脾DC以IL-10依赖的方式获得调节性DC的特性，例如未成熟的表型和增加的IL-10但减少的IL-12产生。这些DC中独特的细胞因子谱似乎受到ERK 1/2和I κ B-NS的调节。这些DC还显示出通过在体内产生产生IL-10的调节性CD 4 T细胞来抑制实验性过敏性脑脊髓炎的发展的能力。这些发现有助于解释V α 14 NKT细胞如何调节体内免疫反应。
V alpha 14 NKT cells exhibit various immune regulatory properties in vivo, but their precise mechanisms remain to be solved. In this study, we demonstrate the mechanisms of generation of regulatory dendritic cells (DCs) by stimulation of V alpha 14 NKT cells in vivo. After repeated injection of a-galactosylceramide (alpha-GalCer) into mice, splenic DCs acquired properties of regulatory DCs in IL-10-dependent fashion, such as nonmatured phenotypes and increased IL-10 but reduced IL-12 production. The unique cytokine profile in these DCs appears to be regulated by ERK1/2 and I kappa B-NS. These DCs also showed an ability to suppress the development of experimental allergic encephalomyelitis by generating IL-10-producing regulatory CD4 T cells in vivo. These findings contribute to explaining how V alpha 14 NKT cells regulate the immune responses in vivo.