An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.
An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.
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DOI：
10.1073/pnas.96.23.13404
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发表时间：
1999-11
影响因子：
11.1
通讯作者：
Jin Yang;H. Bogerd;S. Peng;Heather L. Wiegand;R. Truant;B. Cullen
中科院分区：
文献类型：
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作者：
Jin Yang;H. Bogerd;S. Peng;Heather L. Wiegand;R. Truant;B. Cullen
人类内源性逆转录病毒K （HERV-K）家族的内源性逆转录病毒由每个单倍体人类基因组大约50个原病毒拷贝组成。在这里，HERV-Ks被证明编码一个序列特异性的核RNA输出因子，称为K-Rev，其功能类似于HIV-1 Rev蛋白。与HIV-1 Rev一样，K-Rev结合到Crm1核输出因子和顺式作用的病毒RNA靶标上，激活未剪接RNA的核输出。令人惊讶的是，这个编码在HERV-K长末端重复序列中的HERV-K RNA序列也被HIV-1 rev识别。这些数据为HIV-1和一组大约3000万年前首次进入人类基因组的内源性逆转录病毒之间的进化联系提供了令人惊讶的证据。
The human endogenous retrovirus K (HERV-K) family of endogenous retroviruses consists of approximately 50 proviral copies per haploid human genome. Herein, the HERV-Ks are shown to encode a sequence-specific nuclear RNA export factor, termed K-Rev, that is functionally analogous to the HIV-1 Rev protein. Like HIV-1 Rev, K-Rev binds to both the Crm1 nuclear export factor and to a cis-acting viral RNA target to activate nuclear export of unspliced RNAs. Surprisingly, this HERV-K RNA sequence, which is encoded within the HERV-K long terminal repeat, is also recognized by HIV-1 Rev. These data provide surprising evidence for an evolutionary link between HIV-1 and a group of endogenous retroviruses that first entered the human genome approximately 30 million years ago.