Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice
Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice
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DOI：
10.1016/j.cell.2016.11.016
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发表时间：
2016-12-01
期刊：
影响因子：
64.5
通讯作者：
Gao, George Fu
中科院分区：
文献类型：
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作者：
Ma, Wenqiang;Li, Shihua;Gao, George Fu
寨卡病毒(ZIKV)持续存在于男性患者的精液中，这是黄病毒感染的第一例。在这里，我们证明了ZIKV可以在小鼠的睾丸和附睾处引起炎症，但不能在前列腺或精囊中引起炎症，并且可以在感染后60天后导致睾丸损伤。ZIKV可诱导间质、支持细胞和附睾上皮细胞产生先天免疫反应，从而产生促炎细胞因子/趋化因子。然而，ZIKV不能诱导肾小管周细胞和精原细胞快速而丰富地产生细胞因子，提示这些细胞对ZIKV感染很敏感，可能是ZIKV的潜在保存库。我们的研究证明了ZIKV与睾丸感染/损伤之间的相关性，并表明在某些情况下，ZIKV感染最终会导致男性不育。
Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here, we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in the prostate or seminal vesicle, and can lead to damaged testes after 60 days post-infection in mice. ZIKV induces innate immune responses in Leydig, Sertoli, and epididymal epithelial cells, resulting in the production of pro-inflammatory cytokines/chemokines. However, ZIKV does not induce a rapid and abundant cytokine production in peritubular cell and spermatogonia, suggesting that these cells are vulnerable for ZIKV infection and could be the potential repositories for ZIKV. Our study demonstrates a correlation between ZIKV and testis infection/damage and suggests that ZIKV infection, under certain circumstances, can eventually lead to male infertility.