Maintenance of serological memory by polyclonal activation of human memory B cells
Maintenance of serological memory by polyclonal activation of human memory B cells
复制标题
DOI：
10.1126/science.1076071
复制
发表时间：
2002-12-13
期刊：
影响因子：
56.9
通讯作者：
Lanzavecchia, A
中科院分区：
文献类型：
--
作者：
Bernasconi, NL;Traggiai, E;Lanzavecchia, A
抗体的产生可以持续一生，但其机制仍知之甚少。在这里，我们展示了人类记忆 B 淋巴细胞响应多克隆刺激（例如旁观者 T 细胞帮助和 CpG DNA）而增殖并分化为浆细胞。此外，浆细胞在体内产生的分泌抗体来回忆抗原的水平与特定记忆 B 细胞的频率成正比，甚至在抗原刺激几年后也是如此。尽管抗原加强会导致特异性抗体水平短暂增加，但记忆 B 细胞的持续多克隆激活提供了一种在人类一生中维持血清学记忆的方法。
Production of antibodies can last for a lifetime, through mechanisms that remain poorly understood. Here, we show that human memory B lymphocytes proliferate and differentiate into plasma cells in response to polyclonal stimuli, such as bystander T cell help and CpG DNA. Furthermore, plasma cells secreting antibodies to recall antigens are produced in vivo at levels proportional to the frequency of specific memory B cells, even several years after antigenic stimulation. Although antigen boosting leads to a transient increase in specific antibody levels, ongoing polyclonal activation of memory B cells offers a means to maintain serological memory for a human lifetime.