Morphogen gradient from a noisy source
Morphogen gradient from a noisy source
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DOI：
10.1103/physrevlett.94.078101
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发表时间：
2005-02-25
影响因子：
8.6
通讯作者：
Cardy, J
中科院分区：
文献类型：
--
作者：
England, JL;Cardy, J
我们研究了时间依赖性噪声对发育胚胎中形态发生素梯度形状的影响。微扰理论用于计算鲁棒梯度形成的简单反应扩散模型中确定性行为的偏差，并通过数值模拟验证了结果。研究表明，这种偏差会破坏足够高噪声水平的鲁棒性，并且讨论了这些发现对更复杂的梯度整形路径模型的影响。
We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.