Design and development of cyclohexane-based P,N-ligands for transition metal catalysis
Design and development of cyclohexane-based P,N-ligands for transition metal catalysis
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DOI：
10.1021/ol026249y
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发表时间：
2002-07-25
期刊：
影响因子：
5.2
通讯作者：
Yudin, AK
中科院分区：
文献类型：
--
作者：
Caiazzo, A;Dalili, S;Yudin, AK
[图表]通过在酸性条件下用合适的磷亲核试剂进行氮丙啶开环容易地获得一类新的基于环己烷的P，N-配体。反式-1-氨基-2-二苯基膦基环己烷用酒石酸拆分，产物ee>99%，新配体对磷原子的氧化具有很高的稳定性。
[GRAPHICS]A new class of cyclohexane-based P,N-ligands is readily obtained through aziridine ring opening with suitable phosphorus nucleophiles under acidic conditions. trans-1-Amino-2-diphenylphosphinocyclohexane is resolved with tartaric acid to give the final product in >99% ee. The new ligands show high stability toward oxidation at the phosphorus atom.