The role of long non-coding RNA MIAT in cancers
The role of long non-coding RNA MIAT in cancers
复制标题
DOI：
10.1016/j.biopha.2020.110359
复制
发表时间：
2020-09-01
影响因子：
7.5
通讯作者：
Zhang, Hai-Hong
中科院分区：
文献类型：
--
作者：
Da, Chao-ming;Gong, Chao-Yang;Zhang, Hai-Hong
Long non-coding RNAs (lncRNAs), a kind of non-coding single-strand RNAs, play an important role as carcinogenic genes or tumor suppressors in the development of human cancer. Myocardial infarction-associated transcript (MIAT) was first identified as a lncRNA in 2006 and originally isolated as a candidate gene for myocardial infarction. Later, it was reported that MIAT exhibits regulatory effects on the human cell cycle. Since its discovery, MIAT has also been identified as a carcinogenic regulator in many malignant tumors. High expression of MIAT is related to the clinicopathological characteristics of cancer patients. It can also regulate cell proliferation, invasion, metastasis, and anti-apoptosis through a variety of mechanisms. Therefore, MIAT is considered a potential biomarker and therapeutic target in cancer. In this review, we summarize the biological function, mechanism, and potential clinical significance of MIAT during tumorigenesis.
