Renal baroreceptor-stimulated renin in the eNOS knockout mouse
Renal baroreceptor-stimulated renin in the eNOS knockout mouse
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DOI：
10.1152/ajprenal.0144.2001
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发表时间：
2002-01-01
影响因子：
4.2
通讯作者：
Shesely, EG
中科院分区：
文献类型：
--
作者：
Beierwaltes, WH;Potter, DL;Shesely, EG
以内皮型一氧化氮合酶(ENOS)缺陷小鼠和C57BL/6J(C57)小鼠为对照，研究了内皮源性一氧化氮(NO)在肾素压力感受器刺激中的作用。我们测量了非肌动蛋白麻醉小鼠的血压、肾血流量(RBF)和血浆肾素浓度(PRC)。ENOS基因敲除组小鼠血压明显高于对照组(分别为100+/-3和86+/-1 mm Hg；P
The role of endothelium-derived nitric oxide (NO) in renal baroreceptor stimulation of renin was tested comparing endothelial nitric oxide synthase (eNOS) deficient mice with C57BL/6J (C57) controls. We measured blood pressure, renal blood flow (RBF), and plasma renin concentration (PRC) in Inactin-anesthetized mice. Blood pressure in eNOS knockout mice was higher than in controls (100 +/-3 vs. 86 +/-1 mmHg, respectively; P