Applied Healthspan engineering.
Applied Healthspan engineering.
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DOI：
10.1089/rej.2009.0969
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发表时间：
2010-05
影响因子：
2.6
通讯作者：
J. Larrick;A. Mendelsohn
中科院分区：
文献类型：
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作者：
J. Larrick;A. Mendelsohn
根据荷马史诗《阿佛洛狄忒》，当厄俄斯请求宙斯赐予提托诺斯永生时，她忘了祈求永恒的青春。应用健康跨度工程 (AHE) 致力于解决这个问题。所有生物体都具有维持生命所需的最低水平的功能储备，最终会下降到与死亡时的生存不相容的程度。 AHE 旨在维持或恢复关键组织和器官的最佳功能储备。组织储备与健康相关。饮食、体育锻炼和目前可用的小分子疗法可能会减缓特定器官或器官系统的衰退速度，但不太可能恢复损失的储备。组织稳态和细胞维持中固有的进化衍生的限制需要开发治疗方法来增强再生过程并可能取代整个器官或组织。 AHE 支持细胞、组织和器官稳态机制的研究，以推导出新的再生和组织替代疗法，以延长人类健康的时间。
According to the Homeric Hymn to Aphrodite, when Eos asked Zeus for Tithonus to be granted immortality, she forgot to ask for eternal youth. Applied Healthspan Engineering (AHE) seeks to address this problem. All organisms have a minimal level of functional reserve required to sustain life that eventually declines to a point incompatible with survival at death. AHE seeks to maintain or restore optimal functional reserve of critical tissues and organs. Tissue reserve correlates with well being. Diet, physical exercise, and currently available small-molecule-based therapeutics may attenuate the rate of decline of specific organs or organ systems, but are unlikely to restore lost reserve. Inherent evolutionary-derived limitations in tissue homeostasis and cell maintenance necessitate the development of therapies to enhance regenerative processes and possibly replace whole organs or tissues. AHE supports the study of cell, tissue, and organ homeostatic mechanisms to derive new regenerative and tissue replacement therapies to extend the period of human health.