Cortisol concentrations in 12-to 18-month-old infants: Stability over time, location, and stressor
Cortisol concentrations in 12-to 18-month-old infants: Stability over time, location, and stressor
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DOI：
10.1016/s0006-3223(03)00010-6
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发表时间：
2003-10-01
影响因子：
10.6
通讯作者：
Atkinson, L
中科院分区：
文献类型：
--
作者：
Goldberg, S;Levitan, R;Atkinson, L
背景：有关婴儿下丘脑-垂体-肾上腺(HPA)轴反应性早期发育的信息稀少，限制了我们对应激激素调节和精神病理学易感性的理解。我们考虑了婴儿皮质醇应激反应(CSR)是否适合作为发育应激研究的内分泌表型。方法：我们通过对27名12~18个月的婴儿分别在暴露于两种应激源前、后20分钟和40分钟采集唾液样本，评估了CSR关键参数在时间、地点和应激源之间的稳定性。收集时间匹配的家庭样本以控制昼夜节律并评估基线稳定性。结果：基线皮质醇浓度、峰值百分比变化和曲线下面积(AUC)随时间和应激源的变化而稳定。在两种应激源后，一半的婴儿在应激后20分钟出现皮质醇浓度峰值；另一半在应激后40分钟达到峰值。对于56%的婴儿来说，在不同的压力下，峰值反应时间是不一致的。结论：在人类中，基线和CSR在12到18个月内是稳定的。不同应激源的CSR时程变化表明，婴儿CSR的采样时间应超过30min。结果支持使用婴儿CSR，特别是AUC测量，作为发育应激研究的有效内分泌表型。(C)2003年生物精神病学学会。
Background: Sparse information on early development of hypothalamic pituitary adrenal (HPA) axis responsivity in human infants limits our understanding of stress hormone regulation and vulnerability to psychopathology. We considered whether infant cortisol stress response (CSR) is a suitable endocrine phenotype for developmental stress research.Methods: We assessed stability of key CSR parameters across time, location, and stressor through saliva samples taken before and then 20 and 40 min following exposure to two stressors administered 1 week apart in 27 infants aged 12 to 18 months. Time-matched home samples were collected to control for circadian rhythm and to evaluate baseline stability.Results: Baseline cortisol concentrations, peak percent change, and area under the curve (AUC) were stable across time and stressors. Following both stressors, half the infants exhibited peak cortisol concentrations at 20 min poststress; half peaked at 40 min poststress. For 56% of the infants, peak response time was inconsistent across stressors.Conclusions: In humans, baseline and CSR are stable by 12 to 18 months. Variation in CSR time course across stressors indicates that infant CSR should be sampled beyond 30 min. Results support using infant CSR, particularly as measured by AUC, as a valid endocrine phenotype for developmental stress research. (C) 2003 Society of Biological Psychiatry.