Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers
Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers
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DOI：
10.1016/j.drugalcdep.2008.11.013
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发表时间：
2009-04-01
影响因子：
4.2
通讯作者：
Gutierrez, Sandra
中科院分区：
文献类型：
--
作者：
Zacny, James R.;Gutierrez, Sandra
背景：非医疗用途和滥用处方阿片类药物在美国是一个严重的问题。很少注意评估特定处方阿片类药物的相对精神药理学特征(包括与滥用责任有关的影响)。本研究的目的是在同一受试者中直接比较两种广泛处方和滥用的口服阿片类药物组合的精神药理学特征。方法：20名非药物滥用志愿者参加了一项交叉、随机、双盲研究，所有受试者均服用安慰剂；975 mg对乙酰氨基酚(ACET)；10 mg羟考酮(Oxy)/487 mg ACET；20 mg Oxy/975 mg ACET；15 mg氢可酮(HYD)/487 mg ACET；30 mg HYD/975 mg ACET。Oxy和HYD剂量的选择是为了将这些药物等同于阿片类药物效果的客观衡量标准：缩瞳。依从性测量包括主观效应、精神运动/认知效应、强化效应和生理效应，以及相对效力估计。结果：总的来说，两种阿片类药物在相同剂量下产生相似的原型阿片类药物效应和精神运动损害，且程度相似。高剂量的Oxy/ACET产生的与滥用倾向相关的主观效应比高剂量的Hyd/Oxy略多，但也产生了略多的负面影响。根据多项选择程序的测量，这两种药物都没有起到增强剂的作用。相对效力比显示Oxy/ACET的效力约为Hyd/ACET的1.5倍。结论：与本杂志最近发表的一项研究一致，该研究使用相同剂量的Hyd和Oxy(不含ACET)治疗处方阿片类药物滥用者(Walsh，S.L.，Nuzzo，RA，Lofwall，M.R.，Holtman.J.R.，2008)。处方药物滥用者口服羟考酮、氢可酮和氢吗啡酮的相对滥用倾向评估。依赖毒品和酒精。198,191-202)，我们发现HYD/ACET和Oxy/ACET在非药物滥用志愿者中的药效学作用几乎没有差别。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Non-medical use and abuse of prescription opioids is a significant problem in the United States. Little attention has been paid to assessing the relative psychopharmacological profile (including abuse liability-related effects) of specific prescription opioids. The purpose of this study was to directly compare the psychopharmacological profile of two widely prescribed and abused oral opioid combination products within the same subject.Methods: Twenty non-drug-abusing volunteers participated in a crossover, randomized, double blind Study in which they received, all p.o.: placebo; 975mg acetaminophen (ACET); 10 mg oxycodone (OXY)/487mg ACET; 20mg OXY/975mg ACET; 15 mg hydrocodone (HYD)/487mg ACFT; and 30 mg HYD/975 mg ACET. OXY and HYD doses were chosen to equate the drugs on an objective measure of opiate effects: miosis. Dependent measures were subjective, psychomotor/cognitive, reinforcing, and physiological effects, and relative potency estimates.Results: In general, the two opioid combination Products at equi-miotic doses produced similar prototypic opiate-like effects and psychomotor impairment, and of similar magnitude. The higher dose of OXY/ACET produced slightly more abuse liability-related subjective effects than the higher dose of HYD/OXY, but also produced slightly more negative effects. Neither drug at either dose functioned as a reinforcer, as measured by the Multiple Choice Procedure. Relative potency ratios indicated that OXY/ACET was approximately 1.5 times more potent than HYD/ACET.Conclusions: Consistent with a recent study published in this journal using identical doses of HYD and OXY (without ACET) in prescription opioid abusers (Walsh, S.L., Nuzzo, RA., Lofwall, M.R., Holtman.J.R., 2008. The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription drug abusers. Drug Alcohol Depend. 198, 191-202), we found little difference in the pharmacodynamic effects of HYD/ACET and OXY/ACET in non-drug-abusing volunteers. (C) 2008 Elsevier Ireland Ltd. All rights reserved.