A model for glioma cell migration on collagen and astrocytes
A model for glioma cell migration on collagen and astrocytes
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DOI：
10.1098/rsif.2007.1070
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发表时间：
2008-01-06
影响因子：
3.9
通讯作者：
Grammaticos, B.
中科院分区：
文献类型：
--
作者：
Aubert, M.;Badoual, M.;Grammaticos, B.
我们提出了一个胶质瘤细胞在胶原蛋白和星形胶质细胞基质上迁移的模型。该模型基于元胞自动机，通过适当的进化规则引入各种动力学效应。利用我们的模型，我们研究了同型和异型缝隙结通讯的作用，并表明有可能重现相应的实验迁移模式。特别是，我们证实了实验发现，抑制同型缝隙连接有利于迁移，而异型抑制阻碍迁移。此外，异型缝隙连接抑制效应优于同型抑制效应。
We present a model for the migration of glioma cells on substrates of collagen and astrocytes. The model is based on a cellular automaton where the various dynamical effects are introduced through adequate evolution rules. Using our model, we investigate the role of homotype and heterotype gap junction communication and show that it is possible to reproduce the corresponding experimental migration patterns. In particular, we confirm the experimental findings that inhibition of homotype gap junctions favours migration while heterotype inhibition hinders it. Moreover, the effect of heterotype gap junction inhibition dominates that of homotype inhibition.