Enoxacin Elevates MicroRNA Levels in Rat Frontal Cortex and Prevents Learned Helplessness.
Enoxacin Elevates MicroRNA Levels in Rat Frontal Cortex and Prevents Learned Helplessness.
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DOI：
10.3389/fpsyt.2014.00006
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发表时间：
2014
影响因子：
4.7
通讯作者：
Dwivedi Y
中科院分区：
文献类型：
--
作者：
Smalheiser NR;Zhang H;Dwivedi Y
重度抑郁症（MDD）是一个主要的公共卫生问题。尽管取得了巨大的进展，但与MDD相关的致病机制仍不清楚。此外，大量MDD受试者对目前可用的药物无反应。MicroRNA（miRNAs）是一类通过调节靶mRNA的翻译、mRNA降解或稳定性来控制基因表达的小的非编码RNA。miRNA在疾病病理生理学中的作用正在迅速显现。最近，我们报道了在抑郁自杀受试者的额叶皮层中miRNA表达下调，并且暴露于反复不可避免的休克的大鼠显示出差异性的miRNA变化，这取决于它们是否表现出正常的适应性反应或习得性无助（LH）行为。依诺沙星是一种临床上用作抗菌化合物的氟喹诺酮类药物，可增强体外和体内外周组织中miRNA的产生，但尚未作为研究miRNA表达与神经功能或行为关系的实验工具进行测试。用10或25 mg/kg依诺沙星治疗大鼠1周，增加了额叶皮质中miRNA的表达，并降低了不可避免的休克后表现出LH行为的大鼠比例。进一步的研究是必要的，以了解依诺沙星是否可以改善其他啮齿动物范例和人类临床情况下的抑郁行为，如果是这样，其机制是否是由于上调的miRNA。
Major depressive disorder (MDD) is a major public health concern. Despite tremendous advancement, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small non-coding RNAs that control gene expression by modulating translation, mRNA degradation or stability of mRNA targets. The role of miRNAs in disease pathophysiology is emerging rapidly. Recently, we reported that miRNA expression is down-regulated in frontal cortex of depressed suicide subjects, and that rats exposed to repeated inescapable shock show differential miRNA changes depending on whether they exhibited normal adaptive responses or learned helpless (LH) behavior. Enoxacin, a fluoroquinolone used clinically as an anti-bacterial compound, enhances the production of miRNAs in vitro and in peripheral tissues in vivo, but has not yet been tested as an experimental tool to study the relation of miRNA expression to neural functions or behavior. Treatment of rats with 10 or 25 mg/kg enoxacin for 1 week increased the expression of miRNAs in frontal cortex and decreased the proportion of rats exhibiting LH behavior following inescapable shock. Further studies are warranted to learn whether enoxacin may ameliorate depressive behavior in other rodent paradigms and in human clinical situations, and if so whether its mechanism is due to upregulation of miRNAs.
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影响因子：
16.2
作者：
Edbauer, Dieter;Neilson, Joel R.;Foster, Kelly A.;Wang, Chi-Fong;Seeburg, Daniel P.;Batterton, Matthew N.;Tada, Tomoko;Dolan, Bridget M.;Sharp, Phillip A.;Sheng, Morgan
通讯作者：
Sheng, Morgan
DOI：
10.1073/pnas.1220176110
发表时间：
2013-08-06
影响因子：
11.1
作者：
Cimadamore, Flavio;Amador-Arjona, Alejandro;Terskikh, Alexey V.
通讯作者：
Terskikh, Alexey V.
影响因子：
4.7
作者：
Ruiz CR;Shi J;Meffert MK
通讯作者：
Meffert MK
DOI：
10.1016/j.pnpbp.2010.08.025
发表时间：
2011-06-01
影响因子：
5.6
作者：
Dwivedi, Yogesh;Pandey, Ghanshyam N.
通讯作者：
Pandey, Ghanshyam N.
超越模块和集线器：基因共表达网络研究复杂脑疾病的分子机制的潜力。
DOI：
10.1111/gbb.12106
发表时间：
2014-01
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Gaiteri C;Ding Y;French B;Tseng GC;Sibille E
通讯作者：
Sibille E