Paraneoplastic antibodies coexist and predict cancer, not neurological syndrome
Paraneoplastic antibodies coexist and predict cancer, not neurological syndrome
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DOI：
10.1002/ana.20269
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发表时间：
2004-11-01
影响因子：
11.2
通讯作者：
Lennon, VA
中科院分区：
文献类型：
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作者：
Pittock, SJ;Kryzer, TJ;Lennon, VA
我们研究了553例具有神经系统表现和一种或多种副肿瘤性神经元核或胞质自身抗体的患者血清中共存的自身抗体：抗神经元核自身抗体1型（安娜-1）、安娜-2、安娜-3;浦肯野细胞胞质自身抗体1型（PCA-1）、PCA-2; CRMP-5-免疫球蛋白G或两性蛋白-免疫球蛋白G。除了PCA-1，这单独发生，31%的血清有一个以上的这些自身抗体。此外，25%的血清有神经元钙通道（P/Q型或N型）、钾通道、神经节乙酰胆碱受体、肌肉乙酰胆碱受体或横纹抗体。在副肿瘤性疾病患者中观察到的自身抗体谱意味着靶向多种肿瘤神经抗原并预测患者的肿瘤，但不是特定的神经系统综合征。
We investigated coexisting autoantibodies in sera of 553 patients with a neurological presentation and one or more paraneoplastic neuronal nuclear or cytoplasmic autoantibodies: antineuronal nuclear autoantibody type 1 (ANNA-1), ANNA-2, ANNA-3; Purkinje cell cytoplasmic autoantibody type 1 (PCA-1), PCA-2; and CRMP-5-immunoglobulin G or amphiphysin-immunoglobulin G. Except for PCA-1, which occurred alone, 31% of sera had more than one of these autoantibodies. In addition, 25% of sera had neuronal calcium channel (P/Q-type or N-type), potassium channel, ganglionic acetylcholine receptor, muscle acetylcholine receptor, or striational antibodies. The autoantibody profiles observed in patients with paraneoplastic disorders imply the targeting of multiple onconeural antigens and predict the patient's neoplasm, but not a specific neurological syndrome.