Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products.
Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products.
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肠道微生物群作为预防和治疗 2 型糖尿病的目标_机制和膳食天然产物
DOI：
10.4239/wjd.v12.i8.1146
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发表时间：
2021-08-15
影响因子：
4.2
通讯作者：
Zhou BJ
中科院分区：
文献类型：
--
作者：
Xia F;Wen LP;Ge BC;Li YX;Li FP;Zhou BJ
2型糖尿病（T2 DM）是全球最显著的公共卫生问题之一。越来越多的研究证据表明，肠道菌群的改变在肥胖和T2 DM的发生和发展中起着不可或缺的作用。微生物多样性的减少与胰岛素抵抗和能量代谢有关，特别是厚壁菌门/拟杆菌门比例的上升。代谢物的变化以及随后的肠道菌群失调与T2 DM的存在相关。此外，由肠道菌群失调引起的内毒素渗漏和肠道通透性更是T2 DM发病和进展的触发因素。研究文件表明，天然产物是发现抗T2 DM药物的生物活性剂的显着武库。许多研究表明，天然产物抗2型糖尿病作用的可能机制与其直接或间接调节肠道菌群组成和代谢产物的连续变化密切相关。本文简要介绍了T2 DM的肠道菌群及其相关机制，包括短链脂肪酸、支链脂肪酸的生物合成和代谢、N-氧化三甲胺、胆汁酸信号、内毒素渗漏和肠道通透性，并描述了膳食天然产物如何通过肠道菌群改善T2 DM。
Type 2 diabetes mellitus (T2DM) is among the most remarkable public health concerns globally. Accumulating research evidence documents that alteration of gut microbiota has an indispensable role in the onset and progression of obesity and T2DM. A reduced microbial diversity is linked to insulin resistance and energy metabolism, especially for the rise of the Firmicutes/Bacteroidetes ratio. Changes in metabolites followed by the gut dysbacteriosis are linked to the presence of T2DM. Moreover, endotoxin leakage and gut permeability caused by gut dysbacteriosis is more of a trigger for the onset and progression of T2DM. Research documents that natural products are remarkable arsenals of bioactive agents for the discovery of anti-T2DM drugs. Many studies have elucidated that the possible mechanisms of the anti-T2DM effects of natural products are remarkably linked to its regulation on the composition of gut microflora and the successive changes in metabolites directly or indirectly. This review presents a brief overview of the gut microbiota in T2DM and several relevant mechanisms, including short-chain fatty acids, biosynthesis and metabolism of branched-chain fatty acids, trimethylamine N-oxide, bile acid signaling, endotoxin leakage, and gut permeability, and describes how dietary natural products can improve T2DM via the gut microbiota.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1038/ismej.2014.45
发表时间：
2014-10
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.8
作者：
Brown, AJ;Goldsworthy, SM;Dowell, SJ
通讯作者：
Dowell, SJ
影响因子：
7.7
作者：
den Besten, Gijs;Bleeker, Aycha;Bakker, Barbara M.
通讯作者：
Bakker, Barbara M.
影响因子：
8.2
作者：
Ehses, J. A.;Meier, D. T.;Donath, Marc Y.
通讯作者：
Donath, Marc Y.