Individual variability following 12 weeks of supervised exercise: identification and characterization of compensation for exercise-induced weight loss
Individual variability following 12 weeks of supervised exercise: identification and characterization of compensation for exercise-induced weight loss
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DOI：
10.1038/sj.ijo.0803712
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Blundell, J. E.
中科院分区：
文献类型：
--
作者：
King, N. A.;Hopkins, M.;Blundell, J. E.
目的：研究目的：确定和描述运动引起的能量消耗（EE）变化的个体代偿差异。设计：为期12周的运动干预。受试者：35名超重和肥胖的久坐男性和女性（体重指数，31.8 +/- 4.1千克（-2）;年龄为39.6 ± 11.0岁），在监督条件下每周锻炼5次，持续12周。分别于第0周和第12周测量体重、体成分、静息代谢率（RMR）、每日总能量摄入（EI）和主观食欲感觉。当汇总所有受试者的数据时，（3.7 +/- 3.6 kg）显著（P < 0.0001）和预测，这表明没有补偿EE的增加。然而，进一步检查显示体重变化的个体差异较大（-14.7至+1.7 kg）。根据受试者相对于其预测体重减轻的实际体重减轻（平均NC = 6.3 +/- 3.2 kg和C = 1.5 +/- 2.5 kg），将受试者确定为补偿者（C）或非补偿者（NC）。C和NC的特点是他们不同的代谢和行为补偿反应。C组（-69.2 +/- 268.7 kcal天（-1））和NC组（14.2 +/- 242.7 kcal天（-1））的RMR发生中度变化。在C组中，EI和平均每日主观饥饿增加了268.2 +/- 455.4 kcal/d（-1）和6.9 +/-11.4 mm/d（-1），而EI减少了130 +/- 485 kcal/d（-1），主观食欲没有变化（0.4 +/- 9.6mmday（-1））。结论：这些结果表明，将运动引起的体重变化表示为组平均值掩盖了体重和代偿反应的大的个体间差异。经历低于预期体重减轻的个体正在补偿EE的增加。
Objective: To identify and characterize the individual variability in compensation for exercise-induced changes in energy expenditure (EE).Design: Twelve-week exercise intervention.Subjects: Thirty-five overweight and obese sedentary men and women (body mass index, 31.8 +/- 4.1 kgm(-2); age, 39.6 +/- 11.0 years) were prescribed exercise five times per week for 12 weeks under supervised conditions.Measurements: Body weight, body composition, resting metabolic rate (RMR), total daily energy intake (EI) and subjective appetite sensations were measured at weeks 0 and 12.Results: When all subjects' data were pooled, the mean reduction in body weight (3.7 +/- 3.6 kg) was significant (P < 0.0001) and as predicted, which suggested no compensation for the increase in EE. However, further examination revealed a large individual variability in weight change (-14.7 to +1.7 kg). Subjects were identified as compensators (C) or noncompensators (NC) based on their actual weight loss (mean NC = 6.3 +/- 3.2 kg and C = 1.5 +/- 2.5 kg) relative to their predicted weight loss. C and NC were characterized by their different metabolic and behavioural compensatory responses. Moderate changes in RMR occurred in C (-69.2 +/- 268.7 kcal day(-1)) and NC (14.2 +/- 242.7 kcal day(-1)). EI and average daily subjective hunger increased by 268.2 +/- 455.4 kcal day(-1) and 6.9 +/- 11.4mmday(-1) in C, whereas EI decreased by 130 +/- 485 kcal day(-1) and there was no change in subjective appetite (0.4 +/- 9.6mmday(-1)) in NC.Conclusion: These results demonstrate that expressing the exercise-induced change in body weight as a group mean conceals the large inter-individual variability in body weight and compensatory responses. Individuals who experience a lower than predicted weight loss are compensating for the increase in EE.