The Arp2/3 complex is essential at multiple stages of neural development.
The Arp2/3 complex is essential at multiple stages of neural development.
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DOI：
10.1080/23262133.2016.1261653
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Wang, Pei-Shan
中科院分区：
文献类型：
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作者：
Chou, Fu-Sheng;Wang, Pei-Shan
在神经系统发育过程中，放射状胶质细胞进行自我更新的不对称分裂，形成中间祖细胞(IPC)和神经元。神经元承诺的IPC随后经历多轮瞬时扩增，并在继续分化为成熟神经元的过程中向外迁移形成皮质层。成熟的神经元在其细胞表面延伸突起以形成神经突起，这一过程被称为神经发生。轴突的形成导致突触形成所需的树突和轴突的形成，突触的形成对感觉和运动功能乃至包括记忆形成和认知功能在内的更高水平的功能以及行为和情感的塑造都是必不可少的。神经发育不同阶段的形态适应需要肌动蛋白细胞骨架重塑的积极参与。在这篇综述中，我们旨在讨论目前对Arp2/3复合体分支核因子在不同类型神经细胞发育和成熟过程中的理解。
During development of the nervous system, radial glial cells perform self-renewing asymmetric divisions and give rise to intermediate progenitor cells (IPC) and neurons. The neuronally committed IPC subsequently undergo multiple rounds of transient amplification and migrate outwards to form cortical layers as they continue to differentiate into mature neurons. Maturing neurons extend protrusions on their cell surface to form neurites, a process called neuritogenesis. Neurite formation results in the establishment of dendrites and axons for synapse formation, which is essential for sensory and motor functions and even higher-level functioning including memory formation and cognitive function, as well as shaping of behavior and emotion. Morphological adaptation during various stages of neural development requires active participation of actin cytoskeleton remodeling. In this review, we aim to discuss current understanding of the Arp2/3 complex branching nucleator in various neural cell types during development and maturation.