Tendon injury produces changes in SSCT and nerve physiology similar to carpal tunnel syndrome in an in vivo rabbit model.

Tendon injury produces changes in SSCT and nerve physiology similar to carpal tunnel syndrome in an in vivo rabbit model.
复制标题

DOI：
10.1007/s11552-011-9356-2
复制
发表时间：
2011-12-01
期刊：
Hand (New York, N.Y.)
影响因子：
--
通讯作者：
Amadio, Peter C
Amadio, Peter C
中科院分区：
其他
文献类型：
--
作者：
Moriya, Tamami;Zhao, Chunfeng;Amadio, Peter C

文献摘要

被引文献

相似文献

背景：腕管综合征（CTS）的病因在许多情况下仍然是特发性的。腕管内滑膜下结缔组织（SSCT）的非炎性纤维化在CTS中很常见，一些临床医生假设这种纤维化可能是CTS的原因而不是影响。一个动物模型来检验这一假设将是有用的。本研究的主要目的是探讨手术损伤对在体家兔模型腕管内SSCT纤维化和正中神经功能的影响。方法：手术后12周处死家兔，通过力学测试、组织学、透射和扫描电镜以及电生理学进行评价。结果：SSCT成纤维细胞密度（P < 0.01），正中神经功能恢复正常。
BACKGROUND: The etiology of carpal tunnel syndrome (CTS) remains idiopathic in many cases. Noninflammatory fibrosis of the subsynovial connective tissue (SSCT) within the carpal tunnel is common in CTS, and some clinicians have hypothesized that this fibrosis might be a cause rather than an effect of CTS. An animal model in which to test this hypothesis would be useful. The principal objective of this study was to investigate the effect of a surgical injury on SSCT fibrosis and median nerve function within the carpal tunnel in an in vivo rabbit model.METHODS: Rabbits were sacrificed 12weeks after surgery and were evaluated by mechanical testing, histology, transmission and scanning electron microscopy, and electrophysiology.RESULTS: SSCT fibroblast density (p