Age-related changes in the skeletal muscle cells.
Age-related changes in the skeletal muscle cells.
复制标题
骨骼肌细胞与年龄相关的变化。
DOI：
--
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Z. Göbl
中科院分区：
文献类型：
--
作者：
E. Beregi;O. Regius;T. Hüttl;Z. Göbl
对青年、老年人和CBA/Ca小鼠的骨骼肌细胞进行了电子显微镜观察。老年受试者和小鼠的线粒体呈现与年龄相关的变化。线粒体脊变得不规则间隔，破裂，取而代之的是层状的髓鞘结构。经常可以看到巨大的线粒体。它们在肌原纤维中也含有脂褐素，这往往与受损的线粒体关系密切。将这些线粒体变化与作者早期报告中在淋巴细胞中的变化进行比较，可以说线粒体变化在骨骼肌细胞中比在淋巴细胞中发生得更频繁。
Skeletal muscle cells of young and old humans and CBA/Ca mice were examined electronmicroscopically. The mitochondria in old subjects and mice showed age-related changes. The cristae of mitochondria became irregularly spaced, disrupted and replaced by lamellar, myelin-like structures. Giant mitochondria were often visible. They contain lipofuscin in the myofibrils, too, which was often in close relationship with the damaged mitochondria. Comparing these mitochondrial changes with those demonstrated in the lymphocytes in authors' earlier reports, it can be stated that mitochondrial changes occur more frequently in the skeletal muscle cells than in the lymphocytes.