A study of structural and functional connectivity in early Alzheimer's disease using rest fMRI and diffusion tensor imaging
A study of structural and functional connectivity in early Alzheimer's disease using rest fMRI and diffusion tensor imaging
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DOI：
10.1002/gps.4168
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发表时间：
2015-05-01
影响因子：
4
通讯作者：
Bharath, S.
中科院分区：
文献类型：
--
作者：
Balachandar, R.;John, J. P.;Bharath, S.
背景/目的阿尔茨海默病（AD）是一种进行性神经退行性疾病，早期诊断和干预是痴呆症服务和研究的关键政策重点。我们研究了轻度阿尔茨海默病的功能和结构连通性，以确定阿尔茨海默病早期与神经认知缺陷共存的连通性变化的本质。方法对15例轻度AD患者和15例认知健康对照组（CHc）进行了详细的神经认知评估，并进行了静息状态功能MRI （rs-fMRI）和弥散张量成像（DTI）的磁共振成像（MRI）检查。休息fMRI分析采用双回归方法和体素统计的DTI。结果轻度AD患者的默认模式网络功能连接（FC）明显降低，执行网络功能连接（FC）明显增加。轻度AD组在所有认知领域的得分明显低于CHc组。但分数各向异性差异不显著(p
Background/objectivesAlzheimer's disease (AD) is a progressive neurodegenerative condition where in early diagnosis and interventions are key policy priorities in dementia services and research. We studied the functional and structural connectivity in mild AD to determine the nature of connectivity changes that coexist with neurocognitive deficits in the early stages of AD.MethodsFifteen mild AD subjects and 15 cognitively healthy controls (CHc) matched for age and gender, underwent detailed neurocognitive assessment and magnetic resonance imaging (MRI) of resting state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI). Rest fMRI was analyzed using dual regression approach and DTI by voxel wise statistics.ResultsPatients with mild AD had significantly lower functional connectivity (FC) within the default mode network and increased FC within the executive network. The mild AD group scored significantly lower in all domains of cognition compared with CHc. But fractional anisotropy did not significantly (p