Aberrant interhemispheric functional coordination in patients with HBV-related cirrhosis and minimal hepatic encephalopathy
Aberrant interhemispheric functional coordination in patients with HBV-related cirrhosis and minimal hepatic encephalopathy
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DOI：
10.1007/s11011-014-9505-8
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发表时间：
2014-09-01
影响因子：
3.6
通讯作者：
Teng, Gao-Jun
中科院分区：
文献类型：
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作者：
Chen, Hua-Jun;Wang, Yu;Teng, Gao-Jun
异常的脑功能连接被认为是微小型肝性脑病（MHE）的重要发病机制，然而，对MHE患者大脑半球间连接的改变知之甚少。20例乙肝肝硬化MHE患者和15例健康对照者均行静息态fMRI扫描和弥散张量成像。对称半球间体素之间的功能连接性通过称为体素镜像同伦连接性（VMHC）的技术计算，其中一个半球中每个体素的时间序列与其同伦体素的时间序列相关。采用扩散张量成像测量胼胝体（CC）的平均扩散率（MD）和各向异性分数（FA）值。与对照组相比，MHE患者在额内侧回、上级额灰质、扣带回前部、顶下小叶、中央后回、舌回和枕中回的VMHC降低。MHE患者CC瓣和CC压瓣的FA值显著降低，CC瓣的MD值显著升高。Pearson相关分析显示，扣带回前部/额内侧回VMHC与CC_（10）的FA/MD值相关。这些发现可能提示MHE中异常的半球间协调，并可能为疾病相关机制提供新的见解。
Aberrant brain functional connectivity has been considered as the important mechanism underlying minimal hepatic encephalopathy (MHE); however, little is known about the change in interhemispheric connection in MHE patients. Twenty patients with HBV-related cirrhosis and MHE and 15 healthy controls were included in this study and underwent the resting-state fMRI scanning and diffusion tensor imaging. The functional connectivity between symmetric interhemispheric voxels was computed by a technique called voxel-mirrored homotopic connectivity (VMHC), in which the time series for each voxel in one hemisphere was correlated with that of its homotopic voxel. Diffusion tensor imaging was conducted to measure the mean diffusivity (MD) and fractional anisotropy (FA) values in corpus callosum (CC). Compared with controls, MHE patients showed decreased regional VMHC in medial frontal gyrus, superior frontal gryus, anterior cingulate gyrus, inferior parietal lobule, postcentral gyrus, lingual gyrus, and middle occipital gyrus. MHE patients had significant decreased FA value in CC genu and CC splenium and increased MD value in CC genu. Pearson correlation analyses showed that the VMHC in anterior cingulate gyrus/medial frontal gyrus was correlated with FA/MD values of CC genu. These findings may suggest aberrant interhemispheric coordination in MHE and may provide new insight into the disease-related mechanisms.