HILPDA Is a Prognostic Biomarker and Correlates With Macrophage Infiltration in Pan-Cancer.
HILPDA Is a Prognostic Biomarker and Correlates With Macrophage Infiltration in Pan-Cancer.
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DOI：
10.3389/fonc.2021.597860
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发表时间：
2021
影响因子：
4.7
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Liu C;Zhou X;Zeng H;Wu D;Liu L
背景：缺氧诱导脂滴相关蛋白（HILPDA）在多种肿瘤中差异表达。然而，它的作用和与大多数肿瘤中免疫细胞浸润的相关性仍不清楚。方法：在癌症基因组图谱（TCGA）数据库的泛癌症数据中分析HILPDA表达。使用TCGA的临床生存数据评估HILPDA对临床预后的影响。使用R软件包“clusterProfiler”进行HILPDA的富集分析。我们从已发表的文章中下载TCGA样本的免疫细胞浸润评分，并分析免疫细胞浸润的大小与HILPDA表达之间的相关性。结果如下：在大多数肿瘤类型中，HILPDA高表达并与较差的总生存期、疾病特异性生存期和无进展间期相关。此外，HILPDA表达与糖酵解途径和免疫细胞浸润显著相关。在大多数肿瘤类型中，在具有高HILPDA表达的组织中，肿瘤相关巨噬细胞（TAM）浸润增加。免疫抑制基因PD-L1、PD-1、TGFB 1、TGFBR 1与HILPDA呈正相关。结论：HILPDA是预后不良的标志。高HILPDA可能有助于TAM浸润并与肿瘤免疫抑制状态相关。
Background: The protein hypoxia-inducible lipid droplet-associated (HILPDA) is differentially expressed in various tumors. However, its role and correlation with immune cell infiltration in most tumors remain unclear. Methods: HILPDA expression was analyzed in pan-cancer data from The Cancer Genome Atlas (TCGA) database. The influence of HILPDA in clinical prognosis was evaluated using clinical survival data from TCGA. Enrichment analysis of HILPDA was conducted using the R package “clusterProfiler.” We downloaded the immune cell infiltration score of TCGA samples from published articles and analyzed the correlation between the magnitude of immune cell infiltration and HILPDA expression. Results: HILPDA was highly expressed and associated with worse overall survival, disease-specific survival, and progression-free interval in most tumor types. In addition, HILPDA expression was significantly associated with the glycolysis pathway and infiltration of immune cells. Tumor-associated macrophage (TAM) infiltration increased in tissues with high HILPDA expression in most tumor types. Immunosuppressive genes, such as PD-L1, PD-1, TGFB1, and TGFBR1 were positively correlated with HILPDA. Conclusions: Our study suggests that HILPDA is a marker of poor prognosis. High HILPDA may contribute to TAM infiltration and be associated with tumor immunosuppression status.
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影响因子：
10.3
作者：
Desrichard, Alexis;Kuo, Fengshen;Morris, Luc G. T.
通讯作者：
Morris, Luc G. T.
影响因子：
9.7
作者：
Kim, Sun-Hee;Wang, Dingzhi;Park, Yun-Yong;Katoh, Hiroshi;Margalit, Ofer;Sheffer, Michal;Wu, Hong;Holla, Vijaykumar R.;Lee, Ju-Seog;DuBois, Raymond N.
通讯作者：
DuBois, Raymond N.
影响因子：
12.4
作者：
Chen X;Gao A;Zhang F;Yang Z;Wang S;Fang Y;Li J;Wang J;Shi W;Wang L;Zheng Y;Sun Y
通讯作者：
Sun Y
TOX 与肺腺癌的预后、免疫浸润和 T 细胞耗竭相关
影响因子：
4
作者：
Guo L;Li X;Liu R;Chen Y;Ren C;Du S
通讯作者：
Du S
影响因子：
--
作者：
Applebaum MA;Jha AR;Kao C;Hernandez KM;DeWane G;Salwen HR;Chlenski A;Dobratic M;Mariani CJ;Godley LA;Prabhakar N;White K;Stranger BE;Cohn SL
通讯作者：
Cohn SL