EARLY MENOPAUSE, NUMBER OF REPRODUCTIVE YEARS, AND BONE-MINERAL DENSITY IN POSTMENOPAUSAL WOMEN
EARLY MENOPAUSE, NUMBER OF REPRODUCTIVE YEARS, AND BONE-MINERAL DENSITY IN POSTMENOPAUSAL WOMEN
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DOI：
10.2105/ajph.83.7.983
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发表时间：
1993-07-01
影响因子：
12.7
通讯作者：
BARRETTCONNOR, E
中科院分区：
文献类型：
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作者：
KRITZSILVERSTEIN, D;BARRETTCONNOR, E
目标.先前的研究报道绝经年龄与骨密度呈正相关，初潮年龄与骨密度呈负相关。本研究探讨绝经早期年龄和生育年限（定义为绝经年龄减去初潮年龄）与绝经后妇女骨密度的关系。受试者为555名年龄在60至89岁之间的女性，其中391名为自然绝经，164名为子宫切除术和双侧卵巢切除术。骨密度测量在超远侧手腕，中段桡骨，腰椎和髋关节。绝经早的妇女和生育年限最短的妇女在所有部位的骨密度都显着降低。调整协变量后，绝经年龄和生育年数与各部位骨密度均呈显著正相关，且生育年数对骨密度变异的解释大于初潮年龄或绝经年龄。绝经早或生育年限短的老年妇女骨质疏松症发生率较高。生育年数可能比绝经年龄更有助于识别骨质疏松症风险增加的妇女。
Objectives. Previous studies have reported positive associations of age at menopause with bone density and inverse associations of age at menarche with bone density. This study examined the relationships of early age at menopause and number of reproductive years (defined as age at menopause minus age at menarche) with bone density in postmenopausal women.Methods. The subjects were 555 women aged 60 to 89 years who had had either natural menopause (n = 391) or hysterectomy with bilateral oophorectomy (n = 164). Bone density was measured at the ultradistal wrist, midshaft radius, lumbar spine, and hip.Results. Women who had had early menopause and those with the fewest reproductive years had significantly lower bone density at all sites. After adjustment for covariates, both age at menopause and number of reproductive years had significant positive associations with bone density at every site, and total number of reproductive years explained more of the variance in bone mineral density than did either age at menarche or age at menopause.Conclusions. Elderly women reporting early menopause or fewer reproductive years have more osteoporosis. The number of reproductive years may be more helpful than age at menopause in identifying women at increased risk of osteoporosis.