Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism.
Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism.
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DOI：
10.2741/s350
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发表时间：
2012-06
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影响因子：
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通讯作者：
T. Oyama;H. Uramoto;N. Kagawa;T. Yoshimatsu;T. Osaki;R. Nakanishi;Hisao Nagaya;Kazuhiro Kaneko;M. Muto;T. Kawamoto;F. Tanaka;A. Gotoh
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文献类型：
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作者：
T. Oyama;H. Uramoto;N. Kagawa;T. Yoshimatsu;T. Osaki;R. Nakanishi;Hisao Nagaya;Kazuhiro Kaneko;M. Muto;T. Kawamoto;F. Tanaka;A. Gotoh
肺癌的发生与吸烟有关，吸烟使吸烟者暴露在一系列致癌化学物质中。CYP(细胞色素P450)通常将致癌物代谢成非活性的衍生物，但偶尔也会将这些化学物质转化为更强的致癌物。CYP除了参与致癌物质的代谢外，还参与抗癌药物的激活和/或失活，提示肺癌及其周围组织中CYP的局部表达可能是抗癌药物疗效的重要决定因素。此外，在超过80%的非小细胞肺癌中，雌激素合成酶P450--CYP19(芳香酶)也有表达。这表明雌激素与癌症的发展之间存在关联，这使得芳香酶成为治疗肺癌的一个有吸引力的治疗靶点。1α，25-二羟基维生素D3对肿瘤组织的增殖有抑制作用，并被肺癌组织中经常表达的细胞色素P24转化为其非活性的24-羟基衍生物。因此，了解肿瘤组织中CYP的表达对于开发更好的肺癌治疗方法非常重要，并可能引导我们为个人提供标准化的、量身定做的治疗方法。
The occurrence of lung cancer is associated with smoking, which exposes smokers to a series of carcinogenic chemicals. CYP (cytochrome P450) usually metabolizes carcinogens to their inactive derivatives, but occasionally convert the chemicals to more potent carcinogens. In addition to the metabolism of carcinogenic compounds, CYP also participates in the activation and/or inactivation of anti-carcinogenic agents, suggesting that the local CYP expression in lung cancer and surrounding tissues could be an important determinant of efficacy of anticancer drugs. Furthermore, CYP19 (aromatase), estrogen synthase P450, expressed in more than 80 percent of non-small cell lung cancers. It suggests an association between estrogens and cancer development, which makes aromatase an attractive therapeutic target for the treatment of lung cancer. 1alpha,25-Dihydroxyvitamin D3 has an inhibitory effect on the proliferation of cancer tissues, and is converted to its inactive 24-hydroxylated derivatives by CYP24, which is frequently expressed in lung cancer tissues. Therefore, understanding the CYP expression in tumor tissues is important in developing better therapies for lung cancer, and may lead us to standardized, tailor-made therapies for individuals.