Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren
Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren
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DOI：
10.1111/j.1365-3156.2008.02103.x
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发表时间：
2008-08-01
影响因子：
3.3
通讯作者：
Gazzinelli, Maria Flavia
中科院分区：
文献类型：
--
作者：
Jardim-Botelho, Anne;Raff, Sophia;Gazzinelli, Maria Flavia
目的探讨钩虫和蛔虫感染与儿童韦氏智力量表第三版（WISC-III）（数字跨度、算术和编码）和Raven彩色递进矩阵三个子集成绩的关系。方法对巴西米纳斯吉拉斯州美洲州210名6 - 11岁儿童进行横断面研究。使用单独的比例赔率模型来衡量蠕虫感染强度与四项认知测试中每项测试的不良表现之间的关系。结果在调整性别、年龄、社会经济地位和其他蠕虫感染后，中高强度钩虫感染与WISC-III编码子测试成绩不佳相关[OR = 3.20；95%可信区间(CI) = 1.43-7.17)，钩虫感染强度低与WISC-III编码子测试成绩较差相关[比值比(OR) = 3.71；95% CI = 1.80-7.66]和中至高强度的类蚓蛔虫感染与Raven测试表现不佳相关（OR = 2.03; 95% CI = 1.04-3.99），均与未感染的儿童相比。与仅感染蛔虫感染的儿童相比，同时感染蛔虫感染和钩虫感染的儿童在某些WISC-III亚测试中表现不佳的几率更大。结论这些研究结果表明，钩虫感染可能与较差的注意力和信息处理能力有关（通过WISC-III编码亚测试测量），而蛔虫感染可能与较差的一般智力有关（通过Raven Colored Progressive Matrices测量）。这项研究还提供了证据，证明多寄生虫感染儿童的认知结果比仅感染一种寄生虫的儿童更差。
OBJECTIVE To investigate the relationship between hookworm and Ascaris lumbricoides infection and performance on three subsets of the Wechsler Intelligence Scale for Children - third edition (WISC-III) (Digit Span, Arithmetic and Coding) and Raven Colored Progressive Matrices.METHODS Cross-sectional study of 210 children between the ages of 6 and 11 years in Americaninhas, Minas Gerais, Brazil. Separate proportional odds models were used to measure the association between the intensity of helminth infections and poor performance on each of the four cognitive tests.RESULTS After adjusting for sex, age, socioeconomic status and other helminth infections, moderate-to-high-intensity hookworm infection was associated with poor performance on the WISC-III Coding subtest [OR = 3.20; 95% confidence interval (CI) = 1.43-7.17], low intensity of hookworm infection was associated with poor performance on the WISC-III Coding subtest [odds ratio (OR) = 3.71; 95% CI = 1.80-7.66] and moderate-to-high-intensity A. lumbricoides infection was associated with poor performance on the Raven test (OR = 2.03; 95% CI = 1.04-3.99), all in comparison with uninfected children. Children co-infected with A. lumbricoides infection and hookworm infection had greater odds of poor performance on some WISC-III subtests than children with only A. lumbricoides infection.CONCLUSIONS These findings suggest that hookworm infection may be associated with poorer concentration and information processing skills, as measured on the WISC-III Coding subtest, and that A. lumbricoides infection may be associated with poorer general intelligence, as measured through the Raven Colored Progressive Matrices. This study also presents evidence that polyparasitized children experience worse cognitive outcomes than children with only one helminth infection.