Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilation
Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilation
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DOI：
10.1016/j.media.2008.03.007
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发表时间：
2008-12-01
影响因子：
10.9
通讯作者：
Bodas, Shalmali V.
中科院分区：
文献类型：
--
作者：
Reinhardt, Joseph M.;Ding, Kai;Bodas, Shalmali V.
呼吸系统的主要功能是气体交换。由于许多疾病或损伤条件可引起可改变肺功能的生物力学或材料特性变化，因此对测量区域肺通气和区域比容积变化非常感兴趣。我们描述了一种基于配准的技术，用于从胸部的多个呼吸门控CT图像中估计局部肺扩张。区域肺扩张的程度是用配准位移场的雅可比矩阵（局部偏导数的函数）来测量的，我们表明它与比体积变化直接相关。我们比较了5只麻醉羊在仰卧位上的腹背侧肺扩张模式和基于氙气CT的特定通气测量。使用3D图像配准来匹配在10 cm H(2)O和15 cm H(2)O气道压力下获得的图像，平均雅可比矩阵与氙气CT特定通气之间的匹配最佳（线性回归，平均r(2) = 0.73）。(C) 2008 Elsevier B.V.版权所有
The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation and regional specific volume change. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian (a function of local partial derivatives) of the registration displacement field, which we show is directly related to specific volume change. We compare the ventral-dorsal patterns of lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation in five anesthetized sheep studied in the supine orientation. Using 3D image registration to match images acquired at 10 cm H(2)O and 15 cm H(2)O airway pressures gave the best match between the average Jacobian and the xenon CT specific ventilation (linear regression, average r(2) = 0.73). (C) 2008 Elsevier B.V. All rights reserved.