New plastoquinones isolated from the brown alga, Sargassum micracanthum
New plastoquinones isolated from the brown alga, Sargassum micracanthum
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DOI：
10.1248/cpb.53.1159
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发表时间：
2005-09-01
影响因子：
1.7
通讯作者：
Hayashi, T
中科院分区：
文献类型：
--
作者：
Mori, J;Iwashima, M;Hayashi, T
从微棘马尾藻（Sargassumicracanthum）的甲醇提取物中分离得到四个新的质体醌类化合物。以2-香叶基香叶基-6-甲基-1，4-苯并对苯二酚为原料，经光谱分析和化学转化，确定了它们的结构。这些质体醌具有显著的抗氧化活性，如抑制脂质过氧化作用和清除1，1-二苯基-2-苦肼基（DPPH）自由基的作用。其中一些新的质体醌类化合物对癌细胞株具有细胞毒活性。
Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.