Iron-regulatory proteins: molecular biology and pathophysiological implications.
Iron-regulatory proteins: molecular biology and pathophysiological implications.
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铁调节蛋白：分子生物学和病理生理意义。
DOI：
10.1017/s1462399407000531
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发表时间：
2007-12-05
影响因子：
6.2
通讯作者：
Recalcati, Stefania
中科院分区：
文献类型：
--
作者：
Cairo, Gaetano;Recalcati, Stefania
铁是关键细胞功能所必需的，铁和蛋白质之间有很强的联系。 代谢和重要的代谢过程，如细胞生长，凋亡和 炎症与铁代谢直接或间接相关的疾病 代表着严重的健康问题。铁调节蛋白（IRP）1和2是关键 脊椎动物铁代谢和转录后调节表达的控制器 主要铁稳态基因。在这里，我们讨论IRP系统的失调如何 铁相关和不相关的效应物都可能导致，并解释了这是如何导致 在几种人类疾病中的重要病理后果。
Iron is required for key cellular functions, and there is a strong link between iron metabolism and important metabolic processes, such as cell growth, apoptosis and inflammation. Diseases that are directly or indirectly related to iron metabolism represent major health problems. Iron-regulatory proteins (IRPs) 1 and 2 are key controllers of vertebrate iron metabolism and post-transcriptionally regulate expression of the major iron homeostasis genes. Here we discuss how dysregulation of the IRP system can result from both iron-related and unrelated effectors and explain how this can have important pathological consequences in several human disorders.