Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study.
Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study.
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DOI：
10.1186/1471-2334-13-464
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发表时间：
2013-10-05
影响因子：
3.7
通讯作者：
Supparatpinyo K
中科院分区：
文献类型：
--
作者：
Kawila R;Chaiwarith R;Supparatpinyo K
马尔尼菲青霉病越来越多地出现在没有HIV感染的个体中。本研究旨在比较HIV感染者和未感染者马尔尼菲青霉病的临床和实验室特征。回顾性队列研究于2007年1月1日至2011年12月31日在清迈大学医院进行。我们纳入了年龄≥15岁且经培养证实为马氏假体感染的个体。116名艾滋病毒感染者和34名未感染艾滋病毒的患者入组。与hiv感染患者相比，hiv未感染患者年龄较大；发热、脾肿大和脐部皮肤病变的可能性较小；更容易患斯威特氏综合症和骨关节感染；白细胞计数、血小板计数和CD4细胞计数较高；谷丙转氨酶（ALT）较低；血液真菌培养呈阳性的可能性更小。HIV感染者和未感染者的死亡率分别为20.7%和29.4%。马尔尼菲青霉病的临床表现在HIV感染者和非HIV感染者之间存在差异。医生对未感染艾滋病毒患者的这种疾病的认识可能会促使诊断和及时治疗，并可能导致更好的结果。
Penicilliosis marneffei is increasingly observed in individuals without HIV infection. This study aimed to compare the clinical and laboratory features among HIV infected and uninfected individuals with penicilliosis marneffei. A retrospective cohort study was conducted between January 1, 2007 and December 31, 2011 at Chiang Mai University Hospital. We included individuals who were ≥15 years of age and presented with culture-proven P. marneffei infection. 116 HIV-infected and 34 HIV-uninfected patients were enrolled. Comparing to HIV-infected patients, HIV-uninfected patients were older; less likely to have fever, splenomegaly, and umbilicated skin lesions; more likely to have Sweet’s syndrome and bone and joint infections; had higher white blood cell count, platelet count, and CD4 cell count; had lower alanine transaminase (ALT); and less likely to have positive fungal blood cultures. The mortality rates were 20.7% and 29.4% among HIV infected and uninfected patients, respectively. Clinical manifestations of penicilliosis marneffei are different between patients with and without HIV infection. Physician’s awareness of this disease in HIV-uninfected patients may prompt the diagnosis and timely treatment, and can lead to a better outcome.