The war on cryptococcosis: A Review of the antifungal arsenal.

The war on cryptococcosis: A Review of the antifungal arsenal.
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DOI:
10.1590/0074-02760170391
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发表时间:
2018
影响因子:
2.8
通讯作者:
Perfect JR
Perfect JR
中科院分区:
医学4区
文献类型:
--
作者:
Mourad A;Perfect JR

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隐球菌脑膜炎是当今世界上最常见的中枢神经系统感染。它主要发生在免疫功能低下的个体中,但不完全发生在免疫功能低下的个体中,尽管对艾滋病等临床事件的管理有了实质性的改善,但隐球菌病的病例数仍然很高。不幸的是,尽管有几种抗真菌药物可用于治疗,这种真菌感染的发病率和死亡率仍然很高。在本次评论中,我们将描述成功的治疗方法和策略,识别失败之处,并提供对管理未来发展/改进的见解。这种糖衣酵母可以在人类大脑中造成严重破坏。我们的目标必须是早期预防或诊断疾病,并在发现疾病时使用我们所有的临床工具进行积极治疗。
Cryptococcal meningitis is the most common central nervous system infection in the world today. It occurs primarily, but not exclusively, in immunocompromised individuals and despite substantial improvement in management of clinical events like AIDS, the numbers of cases of cryptococcosis remain very high. Unfortunately, despite several antifungal agents available for treatment, morbidity and mortality rates remain high with this fungal infection. In this Review, we will describe the treatments and strategies for success, identify the failures, and provide insights into the future developments / improvements for management. This sugar-coated yeast can play havoc within the human brain. Our goals must be to either prevent or diagnose disease early and treat aggressively with all our clinical tools when disease is detected.
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发表时间: 2008-08-06
期刊: PloS one
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