Photochemotherapy of hypervascular dermal lesions: A possible alternative to photothermal therapy?
Photochemotherapy of hypervascular dermal lesions: A possible alternative to photothermal therapy?
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DOI：
10.1002/lsm.1900100406
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发表时间：
1990
影响因子：
2.4
通讯作者：
A. Orenstein;J. S. Nelson;L. Liaw;R. Kaplan;S. Kimel;M. Berns
中科院分区：
文献类型：
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作者：
A. Orenstein;J. S. Nelson;L. Liaw;R. Kaplan;S. Kimel;M. Berns
持续改善葡萄酒色斑的激光治疗结果，减少瘢痕形成，将取决于使用激光仅诱导真皮中异常血管的选择性损伤而不损伤正常的上覆表皮的能力。光动力疗法，使用特定波长的光特异性激活的外源性光敏药物，可用于选择性破坏生物系统中的某些靶点。目前的研究表明，在鸡冠模型中，光化学疗法可用于治疗多血管真皮病变，同时使正常的上覆表皮完全完整。
Continued improvement in the results of laser treatment of port wine stain, with reduction in scarring, will depend on the ability to use lasers to induce selective injury of only the abnormal blood vessels in the dermis while sparing the normal overlying epidermis. Photodynamic therapy, using an exogenous photosensitizing drug specifically activated by certain wavelengths of light, may be used to destroy selectively certain targets in biological systems. The current study demonstrates, in the chicken comb model, that photochemotherapy can be used to treat hypervascular dermal lesions while leaving the normal overlying epidermis completely intact.