MicroRNA: Key regulators of oligodendrocyte development and pathobiology
MicroRNA: Key regulators of oligodendrocyte development and pathobiology
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DOI：
10.1016/j.biocel.2015.05.021
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发表时间：
2015-08-01
影响因子：
4
通讯作者：
McDermott, Kieran W.
中科院分区：
文献类型：
--
作者：
Fitzpatrick, John-Mark K.;Anderson, Rebecca C.;McDermott, Kieran W.
MicroRNAs （miRNAs或miRs）是一组小的非编码RNA，通过结合信使RNA （mRNA）靶点并下调基因表达发挥作用。mirna已被证明可以调节许多细胞功能，包括增殖、分化、发育和凋亡。最近，越来越多的证据表明mir参与少突胶质细胞（OL）的规范和发育。特别是，mir -138、-219、-338和-9被归类为OL发育的关键调节因子，在OL谱系的各个点起作用，并影响前体细胞向成熟髓鞘OL的转变。许多研究将mirna与多种中枢神经系统（CNS）疾病的OL和髓磷脂病理联系起来，包括多发性硬化症（MS）、缺血性中风、脊髓损伤和成人发病的常染色体显性白质营养不良（ADLD）。(C) 2015 Elsevier Ltd.版权所有。
MicroRNAs (miRNAs or miRs) are a group of small non-coding RNAs that function through binding to messenger RNA (mRNA) targets and downregulating gene expression. miRNAs have been shown to regulate many cellular functions including proliferation, differentiation, development and apoptosis. Recently, evidence has grown which shows the involvement of miRs in oligodendrocyte (OL) specification and development. In particular, miRs-138, -219, -338, and -9 have been classified as key regulators of OL development, acting at various points in the OL lineage and influencing precursor cell transit into mature myelinating OLs. Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke, spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD). (C) 2015 Elsevier Ltd. All rights reserved.