The intrinsic enzymatic activity of procarboxypeptidase U (TAFI) does not significantly influence the fibrinolytic rate: reply to a rebuttal
The intrinsic enzymatic activity of procarboxypeptidase U (TAFI) does not significantly influence the fibrinolytic rate: reply to a rebuttal
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羧肽酶原 U (TAFI) 的内在酶活性不会显着影响纤溶速率：回复反驳
DOI：
10.1111/j.1538-7836.2007.02593.x
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发表时间：
2007
影响因子：
10.4
通讯作者：
J. Enghild
中科院分区：
文献类型：
--
作者：
Z. Valnickova;I. B. Thøgersen;J. Potempa;J. Enghild
加入procpua时，使用batroxobin （noCPUactivation）诱导凝血，而加入CaCl2（显著CPU激活）诱导凝血时，观察到凝血时间明显延长。总之，我们提供了确凿的证据，证明proCPU在体外不能延长凝块溶解，并且已发表的研究描述了proCPU的抗纤溶作用，而proCPU的体外激活则损害了proCPU的抗纤溶作用。
addition of proCPUwhen batroxobin (noCPUactivation) was used to induce clotting, whereas a significant prolongation was seen when coagulation was induced by addition of CaCl2 (significant CPU activation). In conclusion, we provide firm evidence that proCPU is not able to prolong clot lysis in vitro and that the published study describing an antifibrinolytic effect of proCPU is compromised by in vitro activation of proCPU.
影响因子：
3.4
作者：
J. Weisel
通讯作者：
J. Weisel