Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: Selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density
Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: Selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density
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DOI：
10.1037/0735-7044.110.2.247
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发表时间：
1996-04-01
影响因子：
1.9
通讯作者：
Sarter, M
中科院分区：
文献类型：
--
作者：
McGaughy, J;Kaiser, T;Sarter, M
大鼠被训练在一个先前被验证的行为警觉性任务中，该任务要求它们检测不同长度的视觉信号，并区分信号和非信号事件。基线性能的特点是信号长度依赖于命中得分的能力，命中随着时间的推移而下降，正确的拒绝率约为70%。在大鼠达到任务标准后，将免疫毒素192 igg皂苷或其载体注入基底前脑基底核/ nominata区域。受损大鼠术后表现的特点是检测信号的能力下降，而正确拒绝非信号的能力不受影响。在超过180次的损伤后测试中，损伤的影响没有恢复。大鼠的整体表现与除扣带回和梨状皮质外所有皮质区乙酰胆碱酯酶（AChE）阳性纤维密度相关。这些发现有助于阐明由皮质胆碱能输入丧失引起的注意力障碍的本质。
Rats were trained in a previously validated behavioral vigilance task that required them to detect visual signals of variable length and to discriminate signal from nonsignal events. Baseline performance was characterized by a signal length-dependent ability to score hits, a decline in hits over time, and a correct rejection rate of approximately 70%. After the rats reached criterion performance in this task, the immunotoxin 192 IgG-saporin or its vehicle was infused into the area of the nucleus basalis/substantia innominata of the basal forebrain. Postoperative performance in lesioned rats was characterized by a decrease in their ability to detect signals while their ability to correctly reject nonsignals remained unaffected. The effect of the lesion did not recover in the course of over 180 sessions of postlesion testing. The overall performance of the rats correlated with acetylcholinesterase (AChE)-positive fiber density in all cortical areas measured except the cingulate and pyriform cortex. These findings help to elucidate the nature of the attentional impairments resulting from the loss of cortical cholinergic inputs.