Dopamine D2 receptor mediation of the discriminative stimulus properties of LY 171555 (quinpirole).
Dopamine D2 receptor mediation of the discriminative stimulus properties of LY 171555 (quinpirole).
复制标题
多巴胺 D2 受体介导 LY 171555（喹吡罗）的辨别刺激特性。
DOI：
10.1016/0014-2999(86)90016-6
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发表时间：
1986
影响因子：
5
通讯作者：
Appel,JB
中科院分区：
文献类型：
--
作者：
Weathersby,RT;Appel,JB
采用两级水强化药物辨别实验，分析了多巴胺D2激动剂LY 171555(0.025 mg/kg)对大鼠(N=23)行为影响的机制。替代(泛化)试验表明，DA激动剂阿朴吗啡模拟LY 171555，而选择性D1激动剂SKF 38393不模拟。当与训练药物联合给药时，氟哌啶醇而不是D1拮抗剂SCH 23390剂量依赖地阻断LY 171555线索；单独给药时，SCH 23390模仿LY 171555，氟哌啶醇在与盐水相适应的杠杆上引起反应。这些结果表明，LY 171555的刺激特性主要是由含D2的神经元系统介导的，但在体内刺激D1或D2受体亚型的效果是复杂的和相互依赖的。
The mechanisms subserving the behavioral effects of the putatively selective dopamine D2agonist LY 171555 (0.025 mg/kg) were analyzed in rats (N = 23 using a two-lever, water-reinforced drug discrimination task. Substitution (generalization) tests showed that the DA agonist apomorphine mimicked LY 171555 while the selective D1agonist SKF 38393 did not. When given in combination with the training drug, haloperidol but not the D1antagonist Sch 23390 dose dependently blocked the LY 171555 cue; given alone, Sch 23390 mimicked LY 171555 and haloperidol elicited responding on the saline-appropriate lever. These results suggest that stimulus properties of LY 171555 are mediated primarily by D2-containing neuronal systems but that the effects of stimulating either D1or D2receptor subtypes in vivo are complex and interdependent.