BLOCKING OF ACQUISITION BUT NOT EXPRESSION OF CONDITIONED FEAR-POTENTIATED STARTLE BY NMDA ANTAGONISTS IN THE AMYGDALA
BLOCKING OF ACQUISITION BUT NOT EXPRESSION OF CONDITIONED FEAR-POTENTIATED STARTLE BY NMDA ANTAGONISTS IN THE AMYGDALA
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DOI：
10.1038/345716a0
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发表时间：
1990-06-21
期刊：
影响因子：
64.8
通讯作者：
DAVIS, M
中科院分区：
文献类型：
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作者：
MISERENDINO, MJD;SANANES, CB;DAVIS, M
N-甲基-D-天冬氨酸（NMDA）受体似乎在突触可塑性中起关键作用1 -4。NMDA拮抗剂（如AP 5）防止诱导长时程增强5，6，一种活性依赖性增强突触功效介导的神经机制，也可能是学习和记忆的基础。它们还减弱了几种行为任务中的记忆形成7 -17;然而，很少有数据表明，基于将拮抗剂局部输注到与用于评估条件反射的行为反应紧密耦合的大脑区域中，对条件反射进行NMDA敏感性测量。现在，我们表明，注入杏仁核的NMDA拮抗剂块收购，但不是表达，恐惧条件反射的行为测定介导的一个定义的神经回路（恐惧增强的声音惊吓反射）。这种效应表现出解剖学和药理学的特异性，并不归因于训练中使用的光或电击刺激的显著性降低。这些数据表明，杏仁核中的NMDA依赖性过程有助于联想恐惧条件反射。
RECEPTORS forN-methyl-D-aspartate (NMDA) seem to have a critical role in synaptic plasticity1–4. NMDA antagonists (such as AP5) prevent induction of long-term potentiation5,6, an activity-dependent enhancement of synaptic efficacy mediated by neural mechanisms that might also underlie learning and memory. They also attenuate memory formation in several behavioural tasks7–17; there are few data, however, implicating an NMDA-sensitive measure of conditioning based on local infusion of antagonists into a brain area tightly coupled to the behavioural response used to assess conditioning. We now show that NMDA antagonists infused into the amygdala block the acquisition, but not the expression, of fear conditioning measured with a behavioural assay mediated by a defined neural circuit (fear-potentiation of the acoustic startle reflex). This effect showed anatomical and pharmacological specificity, and was not attributable to reduced salience of the stimuli of light or shock used in training. The data indicate that an NMDA-dependent process in the amygdala subserves associative fear conditioning.