Genes involved in the balance between neuronal survival and death during inflammation.
Genes involved in the balance between neuronal survival and death during inflammation.
复制标题
在炎症期间神经元存活与死亡之间的平衡涉及的基因。
DOI：
10.1371/journal.pone.0000310
复制
发表时间：
2007-03-21
期刊：
影响因子：
3.7
通讯作者：
Rivest, Serge
中科院分区：
文献类型：
--
作者：
Glezer, Isaias;Chernomoretz, Ariel;David, Samuel;Plante, Marie-Michele;Rivest, Serge
Glucocorticoids are potent regulators of the innate immune response, and alteration in this inhibitory feedback has detrimental consequences for the neural tissue. This study profiled and investigated functionally candidate genes mediating this switch between cell survival and death during an acute inflammatory reaction subsequent to the absence of glucocorticoid signaling. Oligonucleotide microarray analysis revealed that following lipopolysaccharide (LPS) intracerebral administration at striatum level, more modulated genes presented transcription impairment than exacerbation upon glucocorticoid receptor blockage. Among impaired genes we identified ceruloplasmin (Cp), which plays a key role in iron metabolism and is implicated in a neurodegenative disease. Microglial and endothelial induction of Cp is a natural neuroprotective mechanism during inflammation, because Cp-deficient mice exhibited increased iron accumulation and demyelination when exposed to LPS and neurovascular reactivity to pneumococcal meningitis. This study has identified genes that can play a critical role in programming the innate immune response, helping to clarify the mechanisms leading to protection or damage during inflammatory conditions in the CNS.
登录
查看更多内容
DOI：
10.1073/pnas.92.7.2539
发表时间：
1995-03-28
影响因子：
11.1
作者：
HARRIS, ZL;TAKAHASHI, Y;GITLIN, JD
通讯作者：
GITLIN, JD
DOI：
10.1196/annals.1306.021
发表时间：
2004-01-01
期刊：
REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS
影响因子：
--
作者：
LeVine, SM;Chakrabarty, A
通讯作者：
Chakrabarty, A
影响因子：
4.7
作者：
Dinkel, K;MacPherson, A;Sapolsky, RM
通讯作者：
Sapolsky, RM
影响因子：
4.8
作者：
Glezer, Isaias;Lapointe, Amelie;Rivest, Serge
通讯作者：
Rivest, Serge
影响因子：
5.3
作者：
Laflamme, N;Lacroix, S;Rivest, S
通讯作者：
Rivest, S