Psychiatric issues in multiple sclerosis
Psychiatric issues in multiple sclerosis
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DOI：
10.1016/j.psc.2007.07.003
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发表时间：
2007-12-01
影响因子：
1.7
通讯作者：
Ehde, Dawn M.
中科院分区：
文献类型：
--
作者：
Chwastiak, Lydia A.;Ehde, Dawn M.
多发性硬化症（MS）是年轻人中最常见的中枢神经系统慢性致残性疾病，在西方国家每1000人中就有1人受到影响[1]。MS是一种中枢神经系统脱髓鞘疾病; MS的诊断需要发生至少两起与中枢神经系统脱髓鞘一致的神经系统事件，这些事件在时间上和解剖学上是分开的。早期发病（通常在20至40岁之间）和疾病持续时间长导致巨大的个人，家庭和社会成本以及生活质量和工作效率的降低[2]。MS具有可变和不可预测的过程，症状可包括虚弱，视力丧失，肠和膀胱失禁。疲劳认知障碍和情绪症状患有MS的人似乎有一些精神症状和疾病的患病率较高（表1）[3-6]。尤其是抑郁和焦虑与治疗依从性降低[7]、功能状态[8]和生活质量[9]相关。本文旨在总结现有文献的流行病学，影响和治疗精神疾病的人谁有MS和确定在哪些领域需要进一步的研究。
Multiple sclerosis (MS) is the most common chronic disabling disease of the central nervous system in young adults, affecting I in 1000 people in Western countries [1]. MS is a demyelinating disease of the central nervous system; a diagnosis of MS requires the occurrence of at least two neurologic events consistent with demyelination in the central nervous system that are separated temporally and anatomically. Early onset (typically between 20 and 40 years of age) and long duration of disease result in tremendous individual, family, and societal costs as well as reductions in quality of life and work productivity [2]. MS has a variable and unpredictable course, with symptoms that can include weakness, visual loss, bowel and bladder incontinence. fatigue. cognitive impairment, and mood symptoms. Persons who have MS seem to have a higher prevalence of a number of psychiatric symptoms and disorders (Table 1) [3-6]. Depression and anxiety, in particular, have been associated with decreased adherence to treatment [7], functional status [8], and quality of life [9]. This article seeks to summarize the existing literature on the epidemiology, impact, and treatment of psychiatric disorders among persons who have MS and to identify the areas in which further research is needed.