Thirteen-year follow up of isolated foveal retinoschisis in a 24-year-old woman
Thirteen-year follow up of isolated foveal retinoschisis in a 24-year-old woman
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DOI：
10.1111/j.1442-9071.2006.01283.x
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发表时间：
2006-08-01
影响因子：
4
通讯作者：
Chelva, Enid S.
中科院分区：
文献类型：
--
作者：
Chen, Fred K.;McAllister, Ian L.;Chelva, Enid S.
视网膜中央凹劈裂症很少在女性中发现。一个11岁的女孩，来自非血缘的父母，提出了双边视力丧失孤立的中心凹视网膜劈裂证实了正常的荧光素血管造影和特征性光学相干断层扫描。精神物理和电生理研究显示轻度对比敏感度丧失，色觉障碍和正常的全视野视网膜电图反应。13年后视力、中心凹视网膜劈裂、视网膜电图、眼电图和视觉诱发反应保持稳定，但注意到图形视网膜电图振幅降低。在RS1基因编码区未发现突变。孤立性中心凹视网膜劈裂可能是黄斑营养不良的一种形式。长期随访可能有助于我们对这种罕见疾病的了解。
Foveal retinoschisis is rarely found in women. An 11-year-old girl, from non-consanguineous parents, presented with bilateral visual loss from isolated foveal retinoschisis as confirmed by a normal fluorescein angiogram and characteristic optical coherence tomogram. Psychophysical and electrophysiological studies demonstrated mild contrast sensitivity loss, dyschromatopsia and normal full field electroretinographic responses. Visual acuity, foveal retinoschisis, electroretinography, electro-oculography and visual evoked responses remained stable after 13 years but a reduction in pattern electroretinography amplitude was noted. No mutation was found in the coding regions of the RS1 gene. Isolated foveal retinoschisis may be a form of macular dystrophy. Longer-term follow up may contribute to our understanding of this rare disease.