Association between Parkinson's disease and risk of colorectal cancer
Association between Parkinson's disease and risk of colorectal cancer
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帕金森病与结直肠癌风险之间的关联
DOI：
10.1016/j.parkreldis.2016.11.011
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发表时间：
2017-02-01
影响因子：
4.1
通讯作者：
Xie, Mingliang
中科院分区：
文献类型：
--
作者：
Xie, Xin;Luo, Xiaoguang;Xie, Mingliang
背景资料：越来越多的证据表明肠道菌群参与了帕金森病（PD）和结直肠癌（CRC）的发病机制，但PD和CRC之间的关系尚未达成共识。为了探讨它们之间的相关性，在此我们总结了流行病学证据，并纳入相关研究进行Meta analysis.Methods：在Medline，Web of Science和Embase中发表的相关文章进行了全面的文献检索，截至2016年6月30日。结果：共纳入13篇文献，采用随机效应模型（Random-effects model.Results.Results.Meta-analysis）进行分析。11项队列研究和2项病例对照研究（包括343，226例PD患者）的汇总结果显示，PD患者发生CRC的风险降低（RR：0.79，95%CI：0.66 - 0.93，P = 0.006）。在西方人群中进行的进一步亚组分析显示，PD和CRC的风险之间的显着负相关性并没有被许多因素，包括研究设计，肿瘤的位置，性别和质量的study.Conclusion：PD患者与CRC的风险降低在西方人群中显着相关。未来的研究需要进一步阐明亚洲人群中的这种关联。(C)2016爱思唯尔有限公司版权所有
Background: Growing evidence has reported that gut microbiota is involved in pathogenesis of Parkinson's disease (PD) and colorectal cancer (CRC), and the association between PD and CRC does not reach a consensus. In order to explore their correlation, herein we summarize the epidemiological evidence and included relevant studies to perform a meta-analysis.Methods: A comprehensive literature search for relevant articles published was performed in Medline, Web of Science and Embase up to June 30, 2016. The pooled risk ratio (RR) with 95% confidence intervals (CI) was used to estimate the effects and calculated using the method of generic inverse variance with the Random-effects model.Results: Thirteen studies were included and analyzed in this meta-analysis. The pooled result of 11 cohort studies and 2 case-control studies comprising 343,226 PD patients showed that patients with PD had a decreased risk of CRC (RR: 0.79, 95% CI: 0.66-0.93, P = 0.006). Further subgroup analyses performed in Western population revealed that the significant inverse association between PD and risk of CRC was not undermined by many factors, including study design, tumor location, gender and quality of the study.Conclusion: Patients with PD was significantly associated with a decreased risk of CRC in Western population. Future studies are warranted to further clarify this association in Asian population. (C) 2016 Elsevier Ltd. All rights reserved.