Vasopressin potentiates ventricular and arterial reflexes in the conscious nonhuman primate.
Vasopressin potentiates ventricular and arterial reflexes in the conscious nonhuman primate.
复制标题
加压素可增强有意识的非人类灵长类动物的心室和动脉反射。
DOI：
10.1152/ajpheart.1989.256.6.h1546
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Cornish,KG
中科院分区：
文献类型：
--
作者：
Barazanji,MW;Cornish,KG
在清醒、无拘束状态下，观察了精氨酸加压素（AVP）对清醒和去交感神经支配（SAD）猴动脉压力感受性反射控制心率（HR）的作用。在静注AVP（2-4 mU·kg ~（-1）·min ~（-1））之前和期间以及在AVP血管拮抗剂“Manning化合物”[（d（CH_2）_5Tyr（Me）]AVP，40 μ g/kg）之后，测定平均动脉血压（MABP）和HR的压力反射曲线，同时保持AVP输注。AVP时动脉压力感受性反射的敏感性（斜率）以及高血压引起的反射性心动过缓均显著增加，并在Manning复合物后恢复至对照水平。还研究了AVP对Bezold-Jorch反射（通过在左心房中注射4微克/千克藜芦啶刺激左心室受体而诱导）的作用。在AVP注射前、注射中及静脉注射复方曼宁后，观察利凡诺定对心血管系统的影响。AVP可明显增强藜芦定引起的低血压和心动过缓，而Manning化合物可减弱这种增强作用。SAD猴的心室反射明显大于正常猴。我们的结论是，在有意识的非人灵长类动物，AVP增强的敏感性的压力反射控制的HR以及Bezold-Jorch反射。在SAD动物中，AVP对Bezold-Jorch反射的增强作用与中枢作用一致，因为压力感受器和心室感受器都在孤束核中有联系。然而，这并不排除外周作用于受体或终末器官的可能性。
The effect of arginine vasopressin (AVP) on the arterial baroreflex control of heart rate (HR) was studied in intact and sinoaortic-denervated (SAD) conscious, unrestrained monkeys. A baroreflex curve for mean arterial blood pressure (MABP) and HR was determined before and during intravenous infusion of AVP (2-4 mU.kg-1.min-1) and after the AVP vascular antagonist "Manning compound" [( d(CH2)5Tyr(Me)]AVP, 40 micrograms/kg), while AVP infusion was kept running. The sensitivity (slope) of the arterial baroreflex, as well as the reflex bradycardia induced by high blood pressure, increased significantly during AVP and returned to the control level after Manning compound. The effect of AVP on the Bezold-Jarisch reflex (induced by stimulating left ventricular receptors with 4 micrograms/kg veratridine injected in the left atrium) was also studied. The cardiovascular responses to veratridine were examined before and during AVP and after administration of Manning compound together with AVP infusion. AVP significantly potentiated the hypotension and the bradycardia produced by veratridine, whereas Manning compound blunted this potentiation. The ventricular reflex in SAD monkeys was significantly greater than in intact monkeys. We conclude that, in the conscious nonhuman primate, AVP potentiates the sensitivity of the baroreflex control of HR as well as the Bezold-Jarisch reflex. The potentiation of the Bezold-Jarisch reflex by AVP in the SAD animals is consistent with a central action, since the baroreceptors and ventricular receptors both have connections in the nucleus tractus solitarius. However, it does not rule out the possibility of peripheral actions on receptors or end organs.