A novel route to the F-ring of halichondrin B. Diastereoselection in Pd(0)-mediated meso and C(2) biol desymmetrization.
A novel route to the F-ring of halichondrin B. Diastereoselection in Pd(0)-mediated meso and C(2) biol desymmetrization.
复制标题
软海绵素 B 的 F 环的新途径。Pd(0) 介导的内消旋和 C(2) 生物去对称化中的非对映选择。
DOI：
10.1021/ol026504e
复制
发表时间：
2002
期刊：
影响因子：
5.2
通讯作者：
Burke,StevenD
中科院分区：
文献类型：
--
作者：
Jiang,Lei;Burke,StevenD
Both σ andC2symmetric diol diacetates were synthesized via two-directional chain elongation. A palladium-mediated, ligand-controlledC2diol desymmetrization provided the desired tetrahydrofuran with the correct relative and absolute stereochemistries. Simple functional group manipulation led to the desired F-ring of halichondrin B. Desymmetrization of themesosubstrate enantioselectively provided the diastereomer, leading to a refinement of our understanding of the transition state model.
